You are giving a bunch of great answers, but still not bridging the chasm between increased oxygen uptake and any possible link to less efficiency. I can't imagine it, but maybe I'm not being clear enough with my question. You used the physiological term "efficiency". It's a well defined term. I know you are a master of physiology, so you don't use physiological terms lightly. To me, this well defined term simply seems disconnected with the rest of your discussion. My basic physiological understanding is that "efficiency" is a ratio percentage of two energy values: propulsion energy / total energywhere "total energy = propulsion energy + wasted energy"When you say that increased oxygen uptake would use up too much fuel and be less efficient, I take this to mean you are talking about THE RATIO decreasing. That is, wasted energy INCREASES when compared to respective changes in propulsion energy. You are only giving partial answers. It's not enough to say heat accumulation is a performance limiter, and oxygen uptake is tightly linked to heat production. To support a claim of less EFFICIENCY, I'm expecting you to compare the different quantities of energies, and explain why the RATIO is changing. Why is it that heat accumulation (or whatever) leads to a smaller percentage of the total energy consumed providing less propulsion in a forward direction? What changes so that our "amazing piece of kit" starts consuming EXCESS energy, only to be wasted before it reaches our feet? A complete answer has to talk about how the relative magnitudes of all the energies involved change.I'm not clear how "elastic return" fits into the discussion either, since that seems to enter the discussion only after efficiency is resolved. Your ability to actively apply forces into the ground can only come from the "propulsion" energy.I completely understand your answers. They answer many questions, but simply don't answer my question. I believe in natural physiology. I also believe in unnatural physiology. I don't talk about EPO specifically, but generally about known "performance enhancing drugs". I don't know why you don't know this already, but I'm actually quite skeptical about the alleged efficacy of EPO, and the alleged reasons for its efficacy. You want to tightly link EPO to oxygen uptake, in order to say oxygen uptake is BS, and therefore EPO is BS. I could agree increased oxygen uptake is BS. But I think you make a mistake to say EPO is only about oxygen uptake. You must already know that my opinion about the efficacy of EPO (for grand tour cyclists) is not about increasing maximum oxygen uptake during exercise (VO2max lasts for 11 minutes, not 3 weeks!), but about faster recovery between exercise. Like the 800m, the 3 week grand tours aren't about doing superhuman things at every stage, but about slowing down the least in the third week, compared to your rivals in the instant tour. And the great cycling experiment of the 1990's and 2000's tells us very little about the direct effects of EPO, despite EPO getting much of the credit, since the cyclists were combining it with everything they believed, or were told, would work. We would need more "controlled" experiments to rule out contributions of other drugs, synergies, and placebo effect. Furthermore, if you want more insight into my beliefs, I think EPO cannot work for marathons, precisely for the reason you claim: it would consume glycogen too quickly. Marathons are in big part about glycogen management. EPO can't help if you only hit the wall sooner. I think EPO can work for 10Ks and 5Ks, but I have faith in Canova that for all these distance events, whatever EPO can do, proper training could do too, at least in large part.I am not laboring under misconceptions about extra muscle mass. You talk about "world records without drugs". Tell me when that's going to happen again for women in 100m, 100m hurdles, 200m, 400m, 800m, 1500m, 3000m, 10000m, long jump, shot put, and discus. Could these same women "perform at their best" without drugs and achieve the same results in "ideal" conditions? Help me understand how all these best performances were possible by these women 20-30 years ago, but not since by any other women?I wouldn't say I despise Lance Armstrong as much as I despise the propaganda. I'm more a champion of truth than a disgruntled cycling fan.Regarding Newton and Einstein, the main difference is there understanding of time. Newton thought it was fixed, while Einstein understood that it depends. Time does funny things at near light speed, or near large masses. Another main difference is era. Einstein is 20th century while Newton was 17th century. I thought this should impress you, as one who wants to drag us forward from 1920 to 1970 physiology into the modern era.