After long runs in the summer my shoes are literally soaked with sweat. I wash my shoes 3-4 times a week in summer, otherwise, I couldn't bring them in the house. They smell like ammonia or worse. I tie the laces so they don't wrap around anything, wash in cold water, normal cycle, spray Shout on the stains, and set out in the sun or a window to dry. It doesn't hurt the shoe. Shoes are designed to run in the rain, so water isn't going to hurt them. On the other hand, clothes dryers get really hot. A dryer could melt the glue or warp the shoe, so I haven't done that in 20 years. I suppose the heat could explode an air bag in a Nike shoe.