whoops, fixing a typo:
I ran CIM yesterday.
Garmin says I climbed 681 ft and descended 1017 feet (that is a net drop of 336, which is close to the 340 foot drop reported on the course map, in which you start at 366' altitude and finish at 26')). Garmin says my min was 16' and max was 362'.
There was plenty of uphill, but there was more downhill.
If you put 681' of climbing and 1017' of descending into the running calculator at runworks.com, you find that you would run 0.5% faster on a perfectly flat course. As a previous poster said, you lose more going up than you gain going down.
Looking at the effects separately, If you climb 681 ft over a marathon (and don't have any downhills at all), the calculator says that you will be 2.5% slower than on flat ground.
If you descend 1,017 ft over a marathon (and don't have any uphills at all), the calculator says that you will 2% faster than on flat ground.
The percentages might come out differently at different speeds; I only input the speed I ran, which is slow (somewhere in the 7's per mile).
The weather was great: temperature and wind, and these make a huge difference in running 26.2.