A post on another thread about running to work inspired me because this is something I've considered doing.
I've procrastinated trying it because I've dismissed being able to manage the logistics of showers, clothes, wallet, and any other necessary odds and ends. I live 4 miles from the office so the distance is easy. I live in the pac NW so the winter weather is primarily running-favorable, if a bit unpleasant at times (like a few weeks here and there like last winter when we were all complaining about snow.) We have a shower in the office and office dress is very casual. So basically, I don't really have a good excuse for not doing this.
One specific question I have is how to best manage running with a backpack (whether its advice about brand, size, straps, etc.) so that it's relatively comfortable and chafe minimal. Other advice is great too.