the 20 x 400 m workout, say at 1500m pace is insane, but if you survive physically and mentally, then you're not going to be afraid of any physical pain, which is the benefit of insane training.
if you're strong mentally, you want to focus on training that makes sense, you do the work that is only enough to provide a response, to adapt and improve.
so, for quality intervals, the question is how much is enough?
as for slower intervals, there is no point, you can just do a 10 mile run up and down hills and run all the hills hard, for much better effect and enjoyment.
for my money, the point of 400m intervals is to develop middle distance speed, that is for the middle distance guy.
for a 100m guy, the 400 is an endurance workout and very valuable at that. i'll skip that idea here.
so, for bread and butter middle distance, you want to run at 800 or mile pace, and volume is four to six, maybe eight, but recovery should be a minute or so, which is to adapt to race pace under fatigue.
that means a centro type guy would do six or eight quarters in 54, but more i'd ask, where's your proof that the extra quarters provide anything but waste energy that is useful tomorrow?
then there is the 800 repeats, perhaps four of them as routine, more for the mental training to deliver under high stress.
that goes one quarter in aerobic threshold and one quarter in desired race finish kick speed.
so for a centro, that would be a 66 second quarter and then a 52 quarter for a 158 800m, and only 3 or 4. in the case of a centro though, there is not much point in doing too much of this type of work, because he has this ability already, and he only wants to do this kind of work to sharpen, to see if he's on top of his game.
a centro wants to figure out the 800m speed endurance better, that is the adaptation he should focus the quality work on.