A recent photo in 'Athletics Weekly' (UK) showed Nick Rose (age 52) to look considerably older than his chronological age (52). A quick survey among friends who are not runners revealed that they thought his age varied from 60 - 70!
Keep in mind that the photo of Rose was taken in the last stages of a race, so his facial expression was strained, to say the least.
However - many athletes in their late thirties and forties look older (subjectively) than their 'real' ages.
Excessive running past 35-40 may have a detrimental effect on appearance, but a lot of this depends on the genetic makeup of the runners in question.
I recall Pierre Levisse (the phenomenal French cross country runner/14 appearances in World Cross/27:50 - 10.000 in 1978) - just one year after turning 40 and winning the French Master's cross country championship - all his hair had turned white by then, giving him the appearance of someone much older.
This is why many people not involved with running assume that distance runners look 'sickly' and 'ill.'
It takes a lot of educating to inform casual observers of the overall benefits of distance running - versus some of the counter effects.