"The one thing that Matt [Tegenkamp] and I were talking about is one thing that he wishes he could have changed that I’m going to try is to have some depletion runs in there. Depletion runs are where you don’t really fuel up beforehand and you don’t really fuel up during and you just feel really drained and light headed. You have to put your body through that every once in a while. He [Matt Tegenkamp] says he wishes he had done that more. They are miserable, but I do think it’s going to be something that helps in that last 10K of the race where no matter how prepared you are, it’s going to hit you hard. That’s what I would recommend to someone transitioning to the marathon."
http://running.competitor.com/2014/03/news/interview-chris-solinsky_96580
I'd like to hear others opinions on this, but this sounds like one the dumbest training ideas I've ever heard. I know the feeling he's talking about and this is more like when you are crashing in a run due to not eating enough or cumulative fatigue, NOT what you experience the last miles of a marathon (unless you haven't been fueling properly). Frankly, this sounds like something someone who has no idea or experience in running would recommend, ala "wear weights around your ankles," or "run a mile at x pace, then do two miles at that pace tomorrow, etc..."
Runs like these seem completely worthless and might due more good than harm if done continually. What would this accomplish, other than to "toughen you up" and would you do that at risk of burn out? Isn't the point of a long run to teach your body how to burn your reserve fuel one your glycogen has been depleted, thus making this type of run unnecessary? And as I pointed out earlier, if you are fueling properly both during and before the race, this won't be the biggest of your concerns, so why subject yourself to this misery?