Can Too Much Exercise Increase Risk of Cancer?

In my opinion, yes, I think too much long term exercise might increase the risk of some cancers by negatively altering the immune system. For those already diagnosed, in my opinion, I think too much volume and intensity of exercise can negatively affect an already compromised immune system.

Richard J Simpson's research group out of the University of Houston investigates immune cells (Natural Killer Cells and T-cells) and exercise. Intensity of exercise and cytomegalovirus (CMV) status (most adults are CMV+) may also play a role, but in general, moderate volume and varied intensity exercise appears protective.

A couple of Simpson's group's studies:

The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood.

https://www.ncbi.nlm.nih.gov/pubmed/22170013

T‐cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256156/

Also, a good review if you can get the full-text:

Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30567-3

and, another interesting review:

Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise

http://www.mdpi.com/2075-4663/6/1/10

If anyone wants to contribute to this understudied emerging area of oncology (exercise-oncology), I recommend supporting AKTIV Against Cancer, co-founded by the late Grete Waitz, they specifically fund exercise-oncology research. Once a year, skip a race and send them the money instead.

Ghost of Igloi, I had: FNHL, Hodgkin's, and DLBC lymphomas. Five years post allogeneic stem cell transplant this Monday. Message me if you have any questions. Also, awaiting the publication of this study:

Increasing physical activity improves survival in lymphoma patients, Mayo researchers say

https://newsnetwork.mayoclinic.org/discussion/increasing-physical-activity-improves-survival-in-lymphoma-patients-mayo-researchers-say/

Ken Martin

@workoutcancer

Anecdotal indeed........ there are no long term studies supporting a positive effect on cancer development or tumor promotion however. That being said, I think it prudent as one gets older, to train more in moderation.

Nice to see a post from you WOC .

I will take a close look at AKTIV . Cancer Sucks.

AKTIV

http://aktivagainstcancer.org/

Opinion on CRISPR ? designer T Cells

like this :

http://lifesciencesjournal.org/2017/05/breakthrough-crispr-car-t-cells/

IMO low intensity stuff like walking really helps the body especially the circulation of the lymphatic system. High intensity that is short with full recovery gives you a boost but at a price ie more mutations pulling the handle on the one arm bandit is always a risk .

btw I am still working on world domination;)

that article was probably written by an obesed guy or maybe a skin guy that just likes eatin salads and sittin on diks.

Thanks to all the well wishers. I have reached out to WOC but my messaging skills are not polished. It is obvious that I cannot change what was done in the past or would I if given a chance. These things a part of me and ingrained at this point in time. What I am more interested in is proceeding from point here and now. I would think competing as a masters track athlete in the 800 meters or 1500 meters would have more positive than negative aspects. Any thoughts?

Charlie,

CAR T therapy for follicular lymphoma is available via clinical trials. It is my understanding that the procedure is beiing fast tracked. But at $400k per treatment it is being reserved for those running out of options. This is my reading of the available information.

Igy

Charlie,

This is another interesting study on High Intensity Interval Training (plus resistance training, and a combination of continuous steady state plus resistance), in young and old adults:

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

http://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30099-2.pdf

Training & supplementary material:

http://www.cell.com/cms/attachment/2118940401/2087011773/mmc1.pdf

There are benefits to higher intensity exercise. However, I think most of us current and former athletes are inclined to overdo it, and for cancer patients I'm more cautious. Personally I try to avoid higher levels of lactate, so I use active recovery (AR) between higher intensity intervals to help clear lactate. My high intensity is around critical velocity (CV) +/- a few seconds, but I keep the intervals short (45 seconds) to keep lactate from building up or reduce the intensity below CV if going longer (e.g. 4 min @ 9.8mph with 1 min AR @ 8.4mph). Example: 12x45s @ 10.4mph with 45s AR @ 8.4mph. I don't feel toasted after this workout, feels good actually, but I don't know my lactate or immune response. I hope to do this workout soon and have lactate taken and VO2 measured.

CRISPER sounds interesting, I've heard many scientist talk excitedly about it. I don't follow it much.

CAR-T cells I think are promising (Jimmy Carter) and I am curious about any synergy with exercise immune response. Additionally, there are some problems with adverse cytokine responses to CAR-T cell therapy, perhaps exercise as a primer might reduce that adverse response.

Ghost of Igloi, I think if you click on my user name 'WOC' you should be redirected to my email. If not, 2contact@workoutcancer.

When you think about free radicals and oxidative stress on DNA then you would come to that conclusion. But I'm willing to bet that's not the complete story.

Duh? wrote:

Everyone dies of something.

If you live a healthy life through exercise then theoretically you may live longer. The longer you live the more exposure you have to environmental causes of cancers. Genetic causes of cancer will have more time to fester and grow in your body. So, basically, living longer will increase your chances of getting cancer.

This. No one gets out alive. And you all get a turn.

Make sure you don't sit around waiting for life to happen to you. We don't all have the same material to start with, and even top quality stuff wears out. My Brother was an Olympic Athlete (6th). Commonwealth Champion. Multiple Pacific Conf Games Champion. Double figure National Champion.

He died at 70.

3 score and 10, and he wasn't a church goer.

[quote]WOC wrote:

https://www.ncbi.nlm.nih.gov/pubmed/22170013

From the abstract:

? "arduous exercise training could compromise host protection to novel pathogens and increase athlete infection risk, although whether or not the composition of naïve and differentiated T cells in blood can serve as prognostic biomarkers in athletes remains to be established."

"Could comprise" & "remains to be established."

From the text:

? "It is acknowledged that this study is limited by the lack of an appropriate control group."

Ken: I reached out to you, hopefully gets there. Rather inept at these things.

On the general comment side, even with my condition, I seem to be performing quite well in comparison to what I have read. Never felt I was overly compulsive exerciser. It was usually over shorter five year periods when younger or older. Probably one reason I only went so far. Other directed in many ways. But all of this is awfully subjective. Sure wish it was more simple.

Igy

Charlie wrote:

Opinion on CRISPR ? designer T Cells

like this :

http://lifesciencesjournal.org/2017/05/breakthrough-crispr-car-t-cells/

You really think Big Pharma is going to release it's grip on it's *50 billion* annual revenue of cancer drugs? ? And think of the additional profit they make from all the drugs that treat the side-effects from cancer treatment drugs.

And we now have contaminated chemo drugs ignored by the drug makers (who would have thought ?):

But rejoice!...rejoice!...everyone! Medical error/treatment is now the *3rd* leading cause of the death in the U.S.! That's a podium position! Iatrogenic damage at it's worst! ?

study_suggests_medical_errors_now_third_leading_cause_of_death_in_the_us

Ken,

I have a couple of questions I would like to get your input on. Could you email me at

reid.harter@gmail.com

? I tried twice to contact using your information and it was kicked back. Thanks.

Igy

Tell It Like It Is wrote:

[quote]WOC wrote:

https://www.ncbi.nlm.nih.gov/pubmed/22170013

From the abstract:

? "arduous exercise training could compromise host protection to novel pathogens and increase athlete infection risk, although whether or not the composition of naïve and differentiated T cells in blood can serve as prognostic biomarkers in athletes remains to be established."

"Could comprise" & "remains to be established."

From the text:

? "It is acknowledged that this study is limited by the lack of an appropriate control group."

And your point? I clearly said "in my opinion", and "might", which is similar to your "Could". Plus, I provided the study link from which you quote. Most runners are dogmatic about running being all good, but one has to consider that not all of it might be beneficial, particularly for cancer patients whom we still know very little about. Not enough research has been done - including with control groups.

Distance running prevents leg cancer but leads to higher risk of arm cancer, as the arms shrivel up and their immune system breaks down.

If you want to live long, adopt a rural lifestyle living mostly off of what you grow. You have cleaner air, meaning less carcinogent exposure.

My grandparents lived to their late 90's and lived a rural country life. I think that is the best. Neither died of cancer. Just old age.

Old age? Mark can you be more specific? When I was a kid "died of old age" meant cancer.

FWIW, my grandmother died at in 2003 at the age of 103 from complications of Alzheimers. But none have her children have lived as long.

Ken your workout is pretty interesting maybe you are on to something I am going to try it . Wake up the neural muscular system with minimal stress .

IMO on exercise is GREAT for your health if not over done.

CRISPR is to DNA what a word processing program is to source code;) Being able to make edits quickly will shorten the development cycle. Cytokine Release Syndrome as well as On Target Toxiticities are much more amenable when you can quickly edit T Cells TCRs . It is an exciting time .

CAR T Cell good video for those that want to learn more

https://youtu.be/BU-V-2qSOjM?t=3309