Not those guys wrote:
SalazarResponds! wrote:There seemed to be some questions over the document Rupp's lawyer gave to USADA. Maybe this is what Salazar is referring to. USADA said it implicated Rupp, obviously Rupp's lawyers don't think so. So one side is wrong about this document. We need to see it.
The document you are referring is a document that states Rupp's dosage as being well within the allowable limit for an IV bag.
However, 4 IV bags were made at the pharmacy the day before.
So, USADA's logic is that because 4 bags were made at the pharmacy, Rupp must have taken all 4 bags.
It's a very weak argument.
Really???
There were 4 x 100 mL L-carnitine IV bags prepared at the pharmacy the day before the The worksheet showed that they were prepared with a concentration of 9.67 grams of L-carnitine/45 mL of saline = 0.2149 grams per mL = 214.9 mg/mL.
An IV infusion of just 1 of the 100 mL bags would be a total dose of 21.49 grams (= 21,490 mg) of L-carnitine. They administered 1 to 4 bags total.
A 100 mL IV of any concentration or dose of L-carnitine without a TUE is an anti-doping rule violation.
A typical IV dose of L-carnitine is 50 mg/kg. = 3,000 mg total dose for a 60 kg. person. It can be given by a slow IV injection over 2 to 3 minutes from a large syringe. The dose of 3,000 mg is only a 15 mL injection of L-carnitine at 200 mg/mL. There is no need for an IV bag and an infusion that lasts over an hour.
However, L-carnitine can be stored for 24 hours with saline in an IV bag and given as a slower IV infusion at a maximum concentration of 8 mg/mL.
The concentration of the L-carnitine IV infusion administered by Dr. Brown was 214.9 mg/mL…which is 26.9X the maximum concentration of 8 mg/mL.
Did Alberto and Dr. Brown inform the 5 NOP athletes that the concentration was 26.9X greater than the maximum concentration for an L-carnitine IV infusion?
Did they inform the 5 NOP athletes of any possible risks or side effects of the L-carnitine infusions?
Did they inform the 5 NOP athletes that the L-carnitine infusions were over the 50 mL limit... without a TUE…and were ADRVs?
https://www.drugs.com/pro/levocarnitine-injection.htmlIt is recommended that a plasma carnitine concentration be obtained prior to beginning this parenteral therapy. Weekly and monthly monitoring is recommended as well. This monitoring should include blood chemistries, vital signs, plasma carnitine concentrations (the plasma free carnitine concentration should be between 35 and 60 μmol/L) and overall clinical condition.
(Some of the NOP athletes had extremely high plasma carnitine concentrations after the IV L-carnitine infusions administered by Dr. Brown for COACH Alberto Salazar.)
Levocarnitine Injection, USP is compatible and stable when mixed in parenteral solutions of Sodium Chloride 0.9% or Lactated Ringer's in concentrations ranging from 250 mg/500 mL (0.5 mg/mL) to 4200 mg/500 mL (8.0 mg/mL) and stored at room temperature (25°C) for up to 24 hours in PVC plastic bags.
In conclusion:
1) COACH Alberto Salazar is not a doctor and needs to be STOPPED.