Has anyone noticed any difficulties with running as you weaned off Lexapro? I started in March and had my last dose on wednesday. In general, I have had few side effects during the weaning process. However, I went running today (my last run was on Tuesday), and my legs felt like lead weights and I had no energy. I was surprised because I wasn't especially tired before or after the run. Who knows? Maybe I just had an off day, but I was wondering whether it could be an effect of coming off of the Lexapro.