Yes, in many cases, the legs can take a pounding in running. This is mainly from the eccentric muscle contractions which become a problem during sustained fast running or too much running down steep hills.
However, you can learn to do lots of fast workouts in each week by becoming more economical. This is why the top runners can do so many awesome workouts. Of course they do get sore legs often, as do cyclists and this requires a recovery period or a change of schedule. I think that one of the biggest mistakes an athlete can make is to follow a training schedule too rigidly, you have to be flexible to allow for those days when things are not flowing smoothly.
It's also true that lactate doesn't cause fatigue.
Actually, there is actually no such thing as production of lactic acid in your body at any time, this was and is a misunderstanding of biochemistry, which will take many decades to be redressed.
The question of red blood cells being damaged, foot strike hemolysis, is a debateable one. I don't believe it is a problem for most runners, since red blood cells are constantly being replaced in a healthy body. The old red blood cells are due to be replaced anyway, so you don't want too many of them circulating in your blood at any one time, because they are less efficient at oxygen transport than new red blood cells, ( this may be one reason why altitude training is effective, because it promotes the production of many new RBC'S)