Kennedy did not go up to altitude until very late in his career when he was past his peak.
During the years when he was on top he trained with the KIM group that was NOT at altitude and they did NOT use altitude tents/houses/whatever.
Kennedy did not go up to altitude until very late in his career when he was past his peak.
During the years when he was on top he trained with the KIM group that was NOT at altitude and they did NOT use altitude tents/houses/whatever.
right! wrote:
Kennedy did not go up to altitude until very late in his career when he was past his peak.
Kennedy has spent 3 weeks, at most, at altitude. I wouldn't consider that "altitude training."
So, some guy makes a statement "never been to altitude, never had a tent" then we see a pic of Kennedy, and a web page with Kennedy as a client, then someone comes along with no more evidence than the first guy and just says stuff - based on what? At least wrong, wrong, wrong has some proof.
Geezus, how stupid do you guys have to be to believe that 3 of the recent best US distance runners all just happen to have the same medical condition and don't suspect that something fishy is going on? All have the same sponsor and one also supposedly has asthma - just think how good Rupp would be if he did not have a thyroid condition and asthma! Two of these guys just happen to have the same coach who has been dogged by drug allegations during his own athletic career and his coaching career, isn't that interesting?
Here's the answer. Go look up the symptoms for hyperthyroidism which is what will happen if someone who has no need for thyroid supplementation takes it and report back to me if they sound like they will aid anyones running.
I'll give you a hint, last time I checked, breathlessness, muscle weakness, problems tolerating heat, increased heart rate, and fatigue don't aid performance. But I could be wrong.
Any of the people who suffer from some sort of hypothyroid condition (myself included) will tell you how much it can mess you up if your levels are off and it is freaking hard to keep them stable. So many things can jack up absorption. FOr example, I have to take my pill with distilled water, b/c some minerals in the faucet water were messing with absorption.
Give up on the conspiracy.
Hell, if you are really interested in trying to use synthetic thyroid as a performance enhancer go look at the old East German drug program. They tried and guess what.....they scraped the whole stupid thing because it made performance way worse! They couldn't figure out how to use it to improve performance and the East German regimin took blood tests like crazy, monitoring everything, looking for an edge.
Also learn something. It's not like the doc just took TSH,T3, and T4 levels and said "hmm thyroid levels are a little off, let's correct them!" They also test for anti thyroid antibodies and do a radioactive iodine test to diagnose the problem to make sure that thyroid levels aren't just elevated b/c of training and such.
Last thing, if you take synthroid or whatever when you don't need it, it completely jacks with your thyroids functioning and impairs it. Basically your natural thyroid function is screwed and it takes a long while to get back to normal. Yep, sounds like a positive thing and something I want!
bodybuilders use it, here's how:
That's T3.
synthroid is T4.
We are talking about T4.
Anyways, did you read the cite you referenced?
THey use it as a fat-loss aid. If you look at what happens when you take synthetic thyroid, you become hyperthyroid. One of the "symptoms" is weight loss. Look at the other symptoms. Body builders don't care about the other stuff to a certain extent, they just have to get the look.
"Both hyper-and hypothyroidism can have severe consequences on an individual, such as goiters and other nasty stuff, so messing with your thyroid is not something I would advise to beginners."
"As with insulin, misuse of this compound can leave you dependent on exogenous T3 for the rest of your life (remember Frank Zane?)...But most importantly, to avoid a crash or a shock to the thyroid function doses need to be built up over time and tapered off again."
After reading that Ruppy had/has hypothyroidism... I finally made the connection with the apparent retardation demonstrated in his interview. Now, it all makes sense and I can cut the guy some slack. Unfortunately, they probably didn't discover his hypothyroidism until it was too late. Oh well, at least he's one heck of a runner.
oh and p.s. - to the guy who posted before me... T3 is the active form... T4 gets converted to T3... the reason you take T4 is because it has a longer half-life in the body. It's all the same.
cdavis wrote:
When looking at those studies it does say that in some cases TSH goes up w/ endurance activity. I am just curious if my doc has not done his research and is overdoing my synthroid because of the effects of my training.
If your TSH is going up, it means that your T3 is going down and you need more, not less synthoid.
Apparently no one does care that most of Salazars athletes all have a prescription for a steroid inhalant. Most are "diagnosed" with exercise induced asthma once they join his clan. hey, it's no conspiracy, just the truth. When a coach sends his athletes to the same doctor, and most of them miraculously have the same condition to get an inhalant to help performance that my friends = gaining an unfair advantage. Douchebags/cheaters in OR unite!
bump
inhalers don't improve performance if you don't have some sort of asthmatic condition....
so it may be morally wrong, but it's not aiding anyone.
Also, the IAAF is pretty stingent on inhalers now a days. You have to have a provocation test done that shows that you actually have asthma. It's not like a doctor can just sign a form anymore.
I don't know if his athletes do or do not use an inhaler. I've never heard of the Gouchers using them and never seen them use one and I've watched Adam race a couple of races, but I could be wrong.
I'm reading SI this week and in particular Part II of the article on steriods and found it interesting that there is a reference to Muhammad Ali revealing after his loss to Larry Homles in 1980 that he had "shed weight after taking an excess of hormone, which had been prescribed for a thyroid condition."
The name of the hormone is not provided nor is the type of thyroid condition, but I found it interesting, especially in light of this previous discussion.
While Rupp has been diagnosed with hyperthyroidism I suppose I am also a little suspicious since as a top US athlete he performs so well despite this condition and needing an inhaler.
Boy Wonder wrote:
I'm reading SI this week and in particular Part II of the article on steriods and found it interesting that there is a reference to Muhammad Ali revealing after his loss to Larry Homles in 1980 that he had "shed weight after taking an excess of hormone, which had been prescribed for a thyroid condition."
The name of the hormone is not provided nor is the type of thyroid condition, but I found it interesting, especially in light of this previous discussion.
While Rupp has been diagnosed with hyperthyroidism I suppose I am also a little suspicious since as a top US athlete he performs so well despite this condition and needing an inhaler.
Yep no one has ever done anything athletic with either of those conditions.
huffer wrote:
Apparently no one does care that most of Salazars athletes all have a prescription for a steroid inhalant. Most are "diagnosed" with exercise induced asthma once they join his clan. hey, it's no conspiracy, just the truth. When a coach sends his athletes to the same doctor, and most of them miraculously have the same condition to get an inhalant to help performance that my friends = gaining an unfair advantage. Douchebags/cheaters in OR unite!
I dont think a sample size of three is adiquit enough to make a claim like this. Look at Adam's times and you wont see a big jump in improvement when he started taking his thyroid meds. (i.e caused from after the australia oly trials and an unfortunate landscaping back injury, didnt start taking them until oregon).
I'd make the bold enough statment that Adam would quit the sport before he would use 'roids'. I dont know anything about the person that Galen is so I wont be as bold with him.
I've been taking my meds for 5 weeks and feel loads better already. I take my meds first thing in the morning and then go for a run, I've noticed that my heart rate is very very high at an easy pace even though I am barely out of breath and feel relaxed and comfortable.
Any one else get this?
Those dimensions are frightening if you believe Conte and his newfound evangelicalism. “There is no [effective] test for insulin, T3 thyroid medication, blood-doping, growth hormone,” he said. “Before Balco, they did 80 per cent of testing in competition and 20 per cent out of competition, but the fact is you have to be pretty stupid to get caught at an event — that’s not a drug test, it’s an IQ test because they taper off ten days beforehand.
What are the odds that this many top level endurance athletes need thyroid drugs?
Zoeller, indisrupters interact with thyroid hormone, a hormone that typically invokes thoughts of energy and metabolism and of thyroid deficiencies among people with weight problems. But in the developing brain, thyroid hormone seems to play a much more important and little-understood role. For example, Zoeller’s work suggests that thyroid hormone directs the production of specialized nerve-supporting brain cells called glial cells. the meantime, has been exploring how endocrine
This is a version of gene doping.
Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1
Yaluan Ma,1 Patricia Freitag,1 Jie Zhou,2 Bernhard Brüne,2 Stilla Frede,1 and Joachim Fandrey1
1University of Duisburg-Essen, Institute of Physiology, D-45147 Essen; and 2University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, D-67663 Kaiserslautern, Germany
Submitted 18 February 2004 ; accepted in final form 14 May 2004
ABSTRACT
TOP
ABSTRACT
MATERIALS AND METHODS
RESULTS
DISCUSSION
GRANTS
REFERENCES
Oxygen is of vital importance for the metabolism and function of all cells in the human body. Hypoxia, the reduction of oxygen supply, results in adaptationally appropriate alterations in gene expression through the activation of hypoxia-inducible factor 1 (HIF-1) to overcome any shortage of oxygen. Thyroid hormones are required for normal function of nearly all tissues, with major effects on oxygen consumption and metabolic rate. Thyroid hormones have been found to augment the oxygen capacity of the blood by increasing the production of erythropoietin (EPO) and to improve perfusion by vasodilation through the augmented expression of adrenomedullin (ADM). Because the hypoxic expression of both genes depends on HIF-1, we studied the influence of thyroid hormone on HIF-1 activation in the human hepatoma cell line HepG2 under normoxic and hypoxic conditions. We found that thyroid hormones increased HIF-1 protein accumulation by increasing HIF-1 protein synthesis rather than attenuating its proteasomal degradation. HIF-1 expression directly correlated with augmented HIF-1 DNA binding and transcriptional activity of luciferase reporter plasmids, whereas HIF-1 levels remained unaffected. Knocking down HIF-1 by short interfering RNA (siRNA) clearly demonstrated that thyroid hormone-induced target gene expression required the presence of HIF-1. Although an increased association of the two known coactivators of HIF-1, p300 and SRC-1, was found, thyroid hormone did not affect the activity of the isolated COOH-terminal transactivating domain of HIF-1. Increased synthesis of HIF-1 may contribute to the adaptive response of increased oxygen demand under hyperthyroid conditions.
hypoxic gene expression; oxygen sensing