As a new age of weight-loss therapeutics dawns, heralded by the likes of semaglutide (Ozempic, Wegovy), scientists are one step closer to creating a drug that can coax muscles into behaving as if they’ve just been put through...
"The mice were also able to run nearly 50% further than prior to treatment"
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This article is not about ozempic at all.
"In a mouse study, SLU-PP-332 ‘revved’ up a natural metabolic pathway that is normally excited through physical exercise. Compared to a control group of obese mice, the cohort given SLU-PP-332 twice a day for a month gained 10 times less fat and also lost 12% of their body weight in the process, with no changes to diet and exercise. "They use more energy just living," Burris said. The mice were also able to run nearly 50% further than prior to treatment, which supports previous research into how it strengthens the heart muscle."
one paragraph later:
"The class of drugs is very different to the emerging weight-loss medicines such as semaglutide, which drastically slow down digestion. However, this could potentially be complementary, since rapid weight loss can also result in a loss of lean muscle."
"The class of drugs is very different to the emerging weight-loss medicines such as semaglutide, which drastically slow down digestion. However, this could potentially be complementary, since rapid weight loss can also result in a loss of lean muscle."
Ozempic and WeGovy are semaglutide... same thing different name
Idk, but Josh Kerr looked pretty lean during that WC final a month back.
Because we're all used to him not being lean. I believe him when he says he just hired a nutritionist tbh. But I will say when I was on Vyvanse being lean was so easy lol
This post was edited 14 seconds after it was posted.
"The class of drugs is very different to the emerging weight-loss medicines such as semaglutide, which drastically slow down digestion. However, this could potentially be complementary, since rapid weight loss can also result in a loss of lean muscle."
Ozempic and WeGovy are semaglutide... same thing different name
Just a suggestion...maybe try reading the article and my post.
This is literally the first paragraph:
"As a new age of weight-loss therapeutics dawns, heralded by the likes of semaglutide (Ozempic, Wegovy), scientists are one step closer to creating a drug that can coax muscles into behaving as if they’ve just been put through a vigorous workout. Known as exercise mimetics, this proposed class of drugs essentially ‘mimics’ the benefits of exercise, triggering a mechanism that supercharges fat metabolism and encourages lean muscle mass."
Then there is this, a few sentences down:
"The class of drugs is very different to the emerging weight-loss medicines such as semaglutide, which drastically slow down digestion. However, this could potentially be complementary, since rapid weight loss can also result in a loss of lean muscle."
I do think there are athletes messing around with insulin and other things like these drugs listed above.
There was a great interview with Dorian Yates (one of the top body builders ever and still a leading mind in the PED world) from a few years ago where he talked about new drugs coming to market that Hollywood had been using for a decade plus quietly. Basically something like insulin that you can cycle to get very lean for a movie role. Models, actresses, guys in super hero movies all use it.
Now a number of famous people have become spokesmen for all of these medications.
I would not be shocked at all of athletes are using something like this, maybe a micro dose. Especially in cycling where power to weight is more important
This might the dumbest thread on letsrun. The article is not about semaglutide, in any of its names.
I feel as if I am watching a comedy sketch in which the main character is trying to explain something and the other characters are made to look ridiculously dumb by not understanding the simple logic of what he is saying, and then pointing to things that he said as if they obviously disprove his point. Except this is actually in real life.
This might the dumbest thread on letsrun. The article is not about semaglutide, in any of its names.
I feel as if I am watching a comedy sketch in which the main character is trying to explain something and the other characters are made to look ridiculously dumb by not understanding the simple logic of what he is saying, and then pointing to things that he said as if they obviously disprove his point. Except this is actually in real life.
I feel as if I am watching a comedy sketch in which the main character is trying to explain something and the other characters are made to look ridiculously dumb by not understanding the simple logic of what he is saying, and then pointing to things that he said as if they obviously disprove his point. Except this is actually in real life.
I'd give it a 50/50 shot that I'm being trolled.
I think the OP and others are just a great example of people who do not read more than the headline (or maybe head note too). Even in the articles you can often see that the writer hasn't read the source (or understood it) which leads to a snowball effect with them exacerbating the problem by creating misleading clickbait titles from their already failed ability to understand what their reference.
There is very small proportion of "trusted journalism" out there anymore. It's a sad state of affairs. Read carefully, then go to the sources and read them. And don't forget to look critically at the sources for issues such as funding and conflicts, errors in protocol etc.
In this case, for example, the research was done on obese mice, etc. etc. - so many parameters of that study that you need to look at and you simply can't jump to the conclusion that the effects observed on an obese mouse will be the same as on an elite athlete.
But, people don't have the ability to read or think, so you have this thread.
I think the OP and others are just a great example of people who do not read more than the headline (or maybe head note too). Even in the articles you can often see that the writer hasn't read the source (or understood it) which leads to a snowball effect with them exacerbating the problem by creating misleading clickbait titles from their already failed ability to understand what their reference.
There is very small proportion of "trusted journalism" out there anymore. It's a sad state of affairs. Read carefully, then go to the sources and read them. And don't forget to look critically at the sources for issues such as funding and conflicts, errors in protocol etc.
In this case, for example, the research was done on obese mice, etc. etc. - so many parameters of that study that you need to look at and you simply can't jump to the conclusion that the effects observed on an obese mouse will be the same as on an elite athlete.
But, people don't have the ability to read or think, so you have this thread.
Yup, you are correct. I think the point of the article was simply to say "there's some cool new drugs coming out in the future that could help with the obesity epidemic" more than anything. To further your point, the article doesn't talk about its effects on elite athletes at all. Just that the new drug class could mimic the effects of exercise and helps with weight loss. Somehow we make the jump that its "the next epo", whatever that is supposed to mean.
I question whether a drug that mimics exercise would be beneficial at all to a person who already exercises excessively. Inadequate training stress is usually not the issue for most semi-serious runners.
Anyway, this thread is idiotic and I'm an idiot for replying.
Didn't read the article. This class of peptides is used for diabetes, weight loss, and in some cases to act as the building blocks of other hormones. They do not mimic exercise but in some cases can stimulate testosterone and or human growth hormone.
Didn't read the article. This class of peptides is used for diabetes, weight loss, and in some cases to act as the building blocks of other hormones. They do not mimic exercise but in some cases can stimulate testosterone and or human growth hormone.
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