Broadway superstar Nick Cordero has leg amputated due to Coronavirus ? How?

This is a sad and accurate post. ECMO has a high complication rate, although it's a choice of ECMO or death (no one is put on ECMO unless it's life or death).

As mentioned above, there is a clotting component to the COVID19 course that we don't fully understand yet. We have identified microclots in the lungs, and some hospitals have adopted blood thinner protocols as standard treatment for ICU COVID19 patients. We've only recently noted increased clotting throughout the body. This was hard to recognize initially, because clotting is often present in severe illness for a variety of reasons. Now we have enough data from enough cases to acknowledge that the rate of clotting is higher in COVID patients than in other ICU patients. We don't know if it is attributable to the body's immune response to the disease or if it's due to the virus itself.

For many people, COVID19 is a mild to moderate illness, but don't underestimate it.

Among medically-related posts I’ve ever seen in 20 years on letsrun, these last few posts are in a rare category of being sensible and accurate. So much garbage posted here by clearly non-medically educated folks opining on things they know absolutely nothing about. So many people with so little knowledge are willing to go by their own grossly inaccurate gut feelings rather than expertise. And often with the underlying suspicion of malfeasance or incompetence on the part of experts (which is the exception, not the rule). Pretty frightening.

Giles Corey wrote:

People, stay away from the hospitals. They kill as many as 425,000 Americans per year per a John Hopkins study.

Yeah, I think I probably *won't* follow medical advice from a guy who doesn't know how to spell "Johns Hopkins."

Sounds like getting outside and moving around to keep the blood flow is good for you still. Interesting.

I’ll suggest that to my next intubated patient.

We have found on autopsy studies that a large number of patients with moderate to severe Covid infections have evidence of arterial and venous “clots.”

And obviously patients who develop these clots in the vessels of the lung will not be able to oxygenate very well.

Hence why we are now treating the very sick patients with blood thinner medication.

The cause of him needing an amputation is not clear but the end result is the same: poor blood supply to the leg that can result in the development of gangrenous tissue that can lead to systemic infection.

Possibilities include:

Severe clots that did not resolve with blood thinner medication or clot busting medication. And maybe he was a poor surgical candidate for a procedure to manually remove a clot “thrombectomy.”

Damage and inflammation to the blood vessels “vasculitis.”

Leg infection/gangrene

Poor blood flow to the leg. Can inadvertently occur sometimes when patients are on high doses of medication to maintain blood pressure. But it should be noted that if this was the case it may usually affect both legs and not just one leg

Giles Corey wrote:

So it was not Covid that cost him his leg but the treatment for Covid.

People, stay away from the hospitals. They kill as many as 425,000 Americans per year per a John Hopkins study.

Are you in a challenge with Wiggins, Facts Matter and Allen53 for dumbness.

Do you know what one leading cause of Covid deaths are due to? Your body's immune response, resulting in cytokine storm.

So you would probably say, "no its not the Covid19, its the treatment your body tried"

I am Sam wrote:

Giles Corey wrote:

So it was not Covid that cost him his leg but the treatment for Covid.

People, stay away from the hospitals. They kill as many as 425,000 Americans per year per a John Hopkins study.

Are you in a challenge with Wiggins, Facts Matter and Allen53 for dumbness.

Do you know what one leading cause of Covid deaths are due to? Your body's immune response, resulting in cytokine storm.

So you would probably say, "no its not the Covid19, its the treatment your body tried"

There is a possibility that thrombosis is triggered by the virus itself, as in SARS 1:

SARS caused process activates NLRP3 -> pyroptosis -> thrombosis

Or maybe those evil doctors and nurses are trying to kill people.

I am Sam wrote:

Giles Corey wrote:

So it was not Covid that cost him his leg but the treatment for Covid.

People, stay away from the hospitals. They kill as many as 425,000 Americans per year per a John Hopkins study.

Are you in a challenge with Wiggins, Facts Matter and Allen53 for dumbness.

Do you know what one leading cause of Covid deaths are due to? Your body's immune response, resulting in cytokine storm.

So you would probably say, "no its not the Covid19, its the treatment your body tried"

Maybe it relates to the endemic of B12 deficiency.

Many of these issues overlap with megaloblastemia. Just say a person likes to party after a show with some whippets. You are a vegan. You unknowingly deplete your B12 stores over time. Pneumonia sets in and causes hypoxia and this time your body actually makes its own EPO. The new blood cells are now megaloblasts. You lose your leg.

B12 can also be related to the cytokine storm. Here is one study that shows metylcobalamin suppressing cytokines in vitro.

Israeli jogger wrote:

I am Sam wrote:

Are you in a challenge with Wiggins, Facts Matter and Allen53 for dumbness.

Do you know what one leading cause of Covid deaths are due to? Your body's immune response, resulting in cytokine storm.

So you would probably say, "no its not the Covid19, its the treatment your body tried"

There is a possibility that thrombosis is triggered by the virus itself, as in SARS 1:

SARS caused process activates NLRP3 -> pyroptosis -> thrombosis

Or maybe those evil doctors and nurses are trying to kill people.

Is it known to directly activate NLRP3? I saw elsewhere that cryopyrin is often associated with anemia.

The vegan humans are so fragile it will be difficult to pinpoint the cause of death.

Purell Frank wrote:

Israeli jogger wrote:

There is a possibility that thrombosis is triggered by the virus itself, as in SARS 1:

SARS caused process activates NLRP3 -> pyroptosis -> thrombosis

Or maybe those evil doctors and nurses are trying to kill people.

Is it known to directly activate NLRP3? I saw elsewhere that cryopyrin is often associated with anemia.

Talking about SARS 1 here, not covid19:

donuts wrote:

Here's an article on "COVID toes" or red rashes that look a bit like frostbite that have been found on many infected people, especially kids and young adults who are otherwise asymptomatic. It's possibly related to blood clotting issues from COVID-19. To early to say for sure. But maybe it's more than just being on a ventilator that caused the blood clots for this guy.

https://www.yahoo.com/gma/covid-toes-could-skin-conditions-offer-coronavirus-clues-172700745.html

Some of the comments say that this skin condition is like psoriasis.

There are many parallels with just having a B12 deficiency.

If it does look like psoriasis, then this is very likely causing an acute deficiency since I think this is a well known connection.

Israeli jogger wrote:

The vegan humans are so fragile it will be difficult to pinpoint the cause of death.

I was just pointing out that we don't know the nutritional status of this person. Most elderly are B12 deficient, but a younger person who is a vegan that does not take a supplement would be in the same category. There are other viruses that cause acute anemia so I am just suggesting that maybe this is one of those.

Israeli jogger wrote:

Purell Frank wrote:

Is it known to directly activate NLRP3? I saw elsewhere that cryopyrin is often associated with anemia.

Talking about SARS 1 here, not covid19:

https://www.ncbi.nlm.nih.gov/pubmed/31231549

This link mentions ORF8b and its dependence on a valine residue.

This interested me because valine is the difference between normal hemoglobin and sickle cell trait hemoglobin. Ethnicities with that trait seem to have been more affected. I think you can have the trait and then have a sickle cell crisis just form going to altitude. This guy has an Italian surname and Italians are known to have that trait. Sickle cell episodes can cause thrombosis. Or if you have that trait, then megaloblastemia is much worse than without it.

I can't say that I understand this, but what made me get on this B12 kick is the the ORF8 protein was suggested to attack porphyrins and suggested it attacks hemoglobin. B12 is a porphyrin analog and so the idea is sort of based on if it can prevent this. I also saw that there is no evidence that it actually gets in your blood cells directly, so this direct attack is probably incorrect.

Here is that link