New British invented doping test could detect EPO use months after injections

Deanouk wrote:

You don’t need huge muscles to run 46.** for a 400m. All the muscle bound collegiates that seem to have no problems running 44 in April while at home in college and then never seem to manage anything matching that on the circuit in Europe peak season, are much more suspicious in my eyes.

I can think of a guy who was running 43.4 at some pokey little meet for free earlier this year but then struggled to break 45 on fast tracks in southern Europe when money was at stake. There was another guy, name rhymes with Ted Burley, who also did exactly this in 2017.

KawauchiFTW wrote:

I'm curious to know how does this new test deal with prolonged time spent at altitude... You know, like spending two months above 10,000+ feet high... That certainly will turn those genes as well, if they are tracking the RBC counts... Just thinking aloud...

What about altitude tents?

1. "The chief drawback of genetic sequencing is the huge cost involved. It requires a genetic sequencer and supercomputer, the combined value of which can be £4 million. However, a Chinese company recently agreed to loan Pitsiladis a sequencer and he has secured funding recently of about £750,000 from Wada, the International Olympic Committee and other sponsors. If additional funding is secured, he is hopeful of having the test in place for the Tokyo Olympics next year. That might be too soon for genetic sequencing to become a sanctionable Wada test, but it could at least provide anti-doping investigators with intelligence."

The supercomputer part of this is pure journalistic BS. The data analysis they use will run on any decent desktop computer. For the sequencing part, you do not typically buy these machines, AFAIK. You rent time on them. Still, full testing of the Olympic Games is a ton of tests, so big bucks.

2. "I wonder who they experimented this one on?"

Quote from their paper: "The blood transcriptional signature of recombinant human erythropoietin administration and implications for anti-doping strategies":

"In a proof-of-principle study, we identified, replicated and validated the whole-blood transcriptional signature of rHuEPO in endurance-trained Caucasian males at sea-level (n = 18) and Kenyan endurance runners at moderate altitude (n = 20), all of whom received rHuEPO injections for four weeks."

thats because everybody does.......all elites from most countries have to dope across most sports,to keep up with the countries where its long been rampant.Do i believe theyre doping in equal numbers?no.More kenyans and ethiopians dope in distance running than anywhere else,because the talent pool is there,and theres more of them.

Subway Surfers wrote:

I will not only lmao when Ethiopia suddenly goes into decline, but burst into little pieces when Yannis's test busts the Robertsons when Yannis did so much for them and they shafted him.

Lol, this would be great ?

This is indeed great news. Especially if it busts the Brits we know are doping their way to mediocrity. I wonder how further decline in their performances will look. Is it possible to run any slower? Oh, they're going to be pathetic.

El Keniano wrote:

This is indeed great news. Especially if it busts the Brits we know are doping their way to mediocrity. I wonder how further decline in their performances will look. Is it possible to run any slower? Oh, they're going to be pathetic.

Sick burn Cleo.

jeff tallon wrote:

thats because everybody does.......all elites from most countries have to dope across most sports,to keep up with the countries where its long been rampant.Do i believe theyre doping in equal numbers?no.More kenyans and ethiopians dope in distance running than anywhere else,because the talent pool is there,and theres more of them.

Pure East African doping apologism.

It doesn't look like it will necessarily catch too many, especially given that it can't be used to find EPO from past years and currently would only last for weeks, not months or not a lot of months, but might decrease the future use of EPO, likely pushing athletes into peptides and other methods not invented in the 1980s. In other words, you better re-test world champs 2019 right now, early November 2019, with this method if you want to catch anyone, because it'll soon be too late.

"They have also discovered that this change in the athlete’s genetic signature will remain detectable for weeks – maybe months – after the doping took place."

Biological passport was also highly touted a few years back. It has not accomplished much.

The fact the Coevett is still allowed to post here shows the site's true colors.

Disgusting.

zxcvczvx wrote:

It doesn't look like it will necessarily catch too many, especially given that it can't be used to find EPO from past years and currently would only last for weeks, not months or not a lot of months,

"They have also discovered that this change in the athlete’s genetic signature will remain detectable for weeks – maybe months – after the doping took place."

But is this true? If the genes are switched on for a few weeks or months after injection, do they not remain 'switched on' in the stored blood sample?

I honestly don't know and have little knowledge of the science behind this, but I'm just wondering if you or anybody knows this (that it can't catch cheats from previous year's stored samples).

"But is this true? If the genes are switched on for a few weeks or months after injection, do they not remain 'switched on' in the stored blood sample?"

Yes, they do remain switched on in the stored samples, if they are treated with this method of analysis in mind (RNA stabilized) at the time of collection.

On the other hand, the genes in stored samples cannot be analyzed, if they were not specially treated at the time of collection. So, in general, old samples will not be analyzable by this technique.

Coevett wrote:

Maybe because you're as retarded as Chad? You honestly think that the UK has such a state sponsored doping program that independent university researchers wouldn't be allowed to design an anti-doping test? And British tabloids and journalists, the most rabid in the world, wouldn't have gotten a sniff of this happening under their noses (aside from dodgy packets sent to professional cyclists)?

Presumably you're American like Chad. Dudes - your best coach just got busted for doping, coach of a project run by the biggest sports company in the world - NIKE, an American company. I know Americans never leave the USA and only ever visit American websites, watch Hollywood movies etc, but seriously dudes, I'll let you into a little secret. Most of the world sees YOU guys as the sinister imperialists (I don't by the way), not the British.

The US as the "sinister imperialists"??? The US, the country that has NEVER invaded and taken over another country or claim on land after a few land disputes with Mexico in the early-mid 1800's? Yeah ok buddy, I'm sure the rest of the world is that stupid to think that. Meanwhile the British have had territorial claims or completely run areas of the world that probably equal 50% of the global landmass sometime within the last 250 years. You need to check your Anti-American bias there buddy, you don't know nearly as much as you think you do Coevett.

another perspective wrote:

The US as the "sinister imperialists"??? The US, the country that has NEVER invaded and taken over another country or claim on land after a few land disputes with Mexico in the early-mid 1800's? Yeah ok buddy, I'm sure the rest of the world is that stupid to think that. Meanwhile the British have had territorial claims or completely run areas of the world that probably equal 50% of the global landmass sometime within the last 250 years. You need to check your Anti-American bias there buddy, you don't know nearly as much as you think you do Coevett.

LOL, what the hell are you talking about? Seems some of you are stuck in the 19th century. Sure the USA can't formally take over countries any more and plant their flag on the government buildings, but they've invaded plenty and installed puppet regimes with their military there to 'protect democracy' etc etc. Other countries they simply had leaders assassinated, agitated and stirred up revolutions (such as the toppling of the pro-Russian democratically elected President), or just used soft economic power to effectively control at least foreign and economic policy in various nations.

BTW, most of the places GB 'invaded' and ruled had aboriginal populations that didn't even have written languages etc. GB is just about the only superpower in history (and relatively we were 10 x as powerful as the USA ever has been) that has virtually never tried to conquer 'modern' populations.

Even half of Americans hate the USA these days. (and again for retards - I don't. I'm one of the biggest supporters of the USA (and Trump) here among non-Americans. Doesn't spare me from the mindless anti-British racism of the likes of Chadlet and Bad Wiggins).

jeff tallon wrote:

thats because everybody does.......all elites from most countries have to dope across most sports,to keep up with the countries where its long been rampant.Do i believe theyre doping in equal numbers?no.More kenyans and ethiopians dope in distance running than anywhere else,because the talent pool is there,and theres more of them.

Cool story bro.

East African doping apologism backed by racist psuedoscience.

Has GB kept up with the Kenyans? Has anyone kept up with the doping Kenyans and Ethiopians?

Subway Surfers wrote:

Deanouk wrote:

You don’t need huge muscles to run 46.** for a 400m. All the muscle bound collegiates that seem to have no problems running 44 in April while at home in college and then never seem to manage anything matching that on the circuit in Europe peak season, are much more suspicious in my eyes.

I can think of a guy who was running 43.4 at some pokey little meet for free earlier this year but then struggled to break 45 on fast tracks in southern Europe when money was at stake. There was another guy, name rhymes with Ted Burley, who also did exactly this in 2017.

I’ve said it before. America is the worst nation for doping in the history of the sport by far.

exrunner wrote:

Subway Surfers wrote:

I can think of a guy who was running 43.4 at some pokey little meet for free earlier this year but then struggled to break 45 on fast tracks in southern Europe when money was at stake. There was another guy, name rhymes with Ted Burley, who also did exactly this in 2017.

I’ve said it before. America is the worst nation for doping in the history of the sport by far.

You think by repeating bs that it makes it true? You clearly can't remember state-sponsored doping in the E Bloc, or the reasons why Russia was banned from Rio, or the activities of the Chinese in the 90's, the disgraceful litany of abuse that is Kenyan doping, and why the US is not on anyone's list of "most at risk of doping" (and I'm not even claiming the US is doping free). It is nowhere near being amongst the worst offenders.

What'll happen is Kenyans and Ethiopians will continue wiping the floor with everyone else in distance running and the old whingers will go back to whining about the new method not working. There will be no decline in East African domination.