My mother-in-law from day one has generally ignored me. When I first met her I tried to introduce myself three times, each time she looked away. Eventually my father-in-law just told me to stop trying.
I have been married to their daughter for about 10 years and we have never had a real conversation. They have never asked me a question beyond, "How are you"
Of course I am sure there are worse stories but this level of engagement with people I have known for over 10 years somehow drives me crazy.