A rare thread where everyone gives good advice and there's no sarcasm. It does sound like you're in 2:40 to 2:45 shape on a good day. I agree with the consensus advice, which I would say is don't try to bank too much time on the early downhills because it will beat up your legs. Still, you are likely to lose a couple of minutes on the uphills between 16-21, and it's hard to get that all back in the last five. So for me personally, a 1-2 minute positive split is about probably optimal, acknowledging that the winner is usually negative splitting.
I came to say, regarding the weather, that usually when it's cool, it's a tailwind. And usually when it's warm, it's a headwind. Some years, with an east wind, it's about 75 degrees from mile 10-21, and while the headwind is not too bad because of the buildings and people, you definitely feel it. The heat can wear you down if you come from a place with winter. I have sometimes taken a drink on one side of the road and then diagonalled to the other side for water to pour, as the aid stations are offset to reduce congestion. The best strategy in any weather is to think the race starts at 16 when you enter the Newton Hills, so don't press too hard before then.
And then, sometimes when it's an east wind, after you crest Heartbreak Hill at 21 miles, and you start the big downhill at Boston College, the temperature drops from 75-80 to about 50 because of the ocean breeze off the bay. And if your legs are beat, you might have trouble with the cold as you try to accelerate for the downhills. I have never run faster than goal pace the last 5 miles, at best I have maintained my average. But I am 58 and aiming for 3:00 to 3:10, weather dependent. You are much fitter than I.
So bottom line is, save a little something for the last 5 miles.
Good luck. I hope we get an epic fast year!