Why and how would someone want convert muscle fiber from Type I to Type II?
Why and how would someone want convert muscle fiber from Type I to Type II?
You would want to because it would make you run faster.
Muscle fibers can be converted, but not by any practical means.
unless ...
Soleus muscles from rats administered T3 exhibited an increased number of type II fibers. Hmmm do we know any lab rats who have been administered T3 lately?
I forget, most of you were educated in public school - T3 = "thyroid hormone". Does that help?
... looks the other way.
If true could this explain the "problem" with AL Sal's group? I read that there is a 1/10,000 chance that a 20-25 year old male would have hypothyroidism. (I don't remember the other stats for other sexes and ages. Also I understand that runners are possibly more prone). Al Sal's group has 3 members with "hypothyroidism."
Sounds fishy to me.
Apparantly your high and mighty private school education didn't work. You should know that rats respond differently and taking a conclusion from a rat study is scientifically retarded. They only provide POSSIBLE clues.
Secondly, the thyroid medication that the \"alleged\" take is T4 (synthroid or levoxyl), NOT T3 (the only one having it being armour). Sorry.
Next conspiracy
Muscle fiber type is determined by the type of motor neuron innervating the cell. Type I fibers are innevated by small motor neurons which respond to low amplitude nerve impulses and thus fire at a lower threshold than the larger motor neurons which innervate type II fibers. Muscle fiber conversion can be produced via a surgical proceedure known as cross-innervation, whereby the nervous innervation of a muscle cell is surgically switched (I have no idea how they do this). Another way to produce fiber conversion is to deprive a muscle cell of all electical stimulation, i.e. as occurs in a paralyzed individual. It has been shown that muscles affected by paralysis are essentially 100% type II.
Here's a clue Buckwheat: T4 is inactive and the body converts T4 into T3, which is active.T3 was also on the list of pharmaceuticals that Victor Conte "prescribed" to his coven of dopers.Also - Rupp is supposed to be asthmatic as well - probably uses albuterol. Google for T3 and Albuterol ... at the same time and follow the links that you find. Here's your next clue Buckwheat - "well golly gee letsrunners, all these links go to steroids.com, ripped.com, pumpmeup.com, anabolics.com victorconte.com - whudduh you suppose that means?"With this, I bid you all a good evening.
curiously wrote:
Apparantly your high and mighty private school education didn't work. You should know that rats respond differently and taking a conclusion from a rat study is scientifically retarded. They only provide POSSIBLE clues.
Secondly, the thyroid medication that the "alleged" take is T4 (synthroid or levoxyl), NOT T3 (the only one having it being armour). Sorry.
Next conspiracy
The main value of triiodothyronine (T3) as a performance-enhancer is that it increases the expression of the MCT4 (monocarboxylate transport) isoform. In conjunction with regular "crest-load" running, this enables muscle fibers (mainly Type II fibers) to process more lactate as a fuel at moderate to high intensities (above the ventilatory threshold). T3 therefore dramatically increases the effectiveness of hard endurance work.
I am in the school of thought that full conversion is not possible in humans (aside from surgical cross-inervation), but endurance training will make the Type II fibers perform more like Type I fibers. More aerobic enzymes, more mitochondria.
The opposite does not seem to be as common--that is I--->II.
There is a saying "A trained muscle is a slow muscle".
My muscle fibers have converted to Kabahla.
Well, that shows what you know.
luv2run wrote:
I am in the school of thought that full conversion is not possible in humans (aside from surgical cross-inervation), but endurance training will make the Type II fibers perform more like Type I fibers. More aerobic enzymes, more mitochondria.
The opposite does not seem to be as common--that is I--->II.
There is a saying "A trained muscle is a slow muscle".
Incognito McFisto wrote:
Well, that shows what you know.
luv2run wrote:I am in the school of thought that full conversion is not possible in humans (aside from surgical cross-inervation), but endurance training will make the Type II fibers perform more like Type I fibers. More aerobic enzymes, more mitochondria.
The opposite does not seem to be as common--that is I--->II.
There is a saying "A trained muscle is a slow muscle".
Please, educate me then.
so why does rupp get off? Is this scenario really that unlikely:
Al Sal knows T3 and asthma medication improve performance. Waits for Galen to have a bad month of training and asks if he feels tired. Of course all elite runners feel sluggish at times so Galen says he does. Al Sal "refers" him to a doctor he knows will make this diagnosis. Now voila Galen is legally taking PED's.
Yes, I searched those wonderful websites you told me too.
T3 and albuterol combined was widely touted as an excellent fat burner...just what Galen needs, a fat burner. The guys running 100+mpw probably. He's not a bodbuilder looking to lose an extra pound.
Exactly.
The same can be said for low testosterone - most endurance athletes have low t, not saying that this is the case ... but ... if you were to put in a high mileage week or back to back weeks capping off with a long run and have your t tested, it would come back low enough to get a prescription and/or TUE. "Normal" t levels are higher than average for the competitive distance runner.
Concerning thyroid levels, in a normal person even back to back weeks of hard training would not raise the levels to the degree needed for treatment.
Also, any competent doctor does not just use a thyroid panel to diagnose hypothyroidism. That is only the first step. If something shows up out of whack, they go through a whole slew of other tests to diagnose the problem.
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