Obama knew that his Peace Prize, awarded by a different institute, was premature. The context of the time was that the Bush administration had pushed multiple wars, torture, and lawlessness for 8 years before he took office. Bush had divided Europe and there was a civil war raging in Iraq (hundreds of thousands of Iraqis had died already from the invasion and civil war) and worse in Afghanistan. So, when Obama came in, he reset the relations between the U.S. and Europe and peace, rather than war, was on the agenda. The Arab Spring prompted hopes of widespread democratization with the loss of support to the old dictatorships and oligarchies. Many of these hopes didn't pan out but we didn't start any new wars and he wrapped up the Iraq war.
I think the mRNA delivery tech is an excellent and amazing development that's very deserving of recognition.
At the same time, I wish the roll out of it would have been less forced, more natural, and more measured. I am not sure if the pandemic actually helped this development in the long term.
Only one small company was working with mRNA vaccine and couldnt get it to work until covid happened. I would say the opposite, Covid was 99% the key.
The delivery mechanism is a true breakthrough and lends itself to targeted treatments for cancer that should be far less destructive than radiation or chemotherapy. As a vaccine, it is suitable for those for whom it provides a net benefit (elderly, obese and the immuno compromised). Like all treatments, it is not without its risks (which those on the mandate side never were able to acknowledge). The main criticism I have had for this invention has not been for the invention itself, but for the government that has attempted to obscure from the public an accurate risk / benefit profile.
Obama knew that his Peace Prize, awarded by a different institute, was premature. The context of the time was that the Bush administration had pushed multiple wars, torture, and lawlessness for 8 years before he took office. Bush had divided Europe and there was a civil war raging in Iraq (hundreds of thousands of Iraqis had died already from the invasion and civil war) and worse in Afghanistan. So, when Obama came in, he reset the relations between the U.S. and Europe and peace, rather than war, was on the agenda. The Arab Spring prompted hopes of widespread democratization with the loss of support to the old dictatorships and oligarchies. Many of these hopes didn't pan out but we didn't start any new wars and he wrapped up the Iraq war.
This is exactly right. On paper, no way anyone had more impact on peace than Obama that year, due in large part to coming in behind Bush and the fact that the POTUS can do a lot more than any one person can can with his pen. The flip side is it wasnt exactly made for TV type stuff, so it appeared to the uninitiated that he was just doing "president stuff". Both Obama and Biden had to do major repair after their predecessors. Obama had to reset world relations. The whole of the GOP was mad that he was apologizing for our bad behavior. Turned out to be small potatoes compared to what DT brought to table.
Treatment for cancer and such is exactly what it should be used for. I'll pass on the regular booster shots for Covid.
Amen.
No one has ever really got a cancer vaccine to work, aside from viral cancers. Cancers necessarily have to become immune invisible to proliferate.
It’s also hyper-personalized (each person needs tumor sequencing or TIL TCR sequencing and a cell product made) and the current trials cost millions per person.
The delivery mechanism is a true breakthrough and lends itself to targeted treatments for cancer that should be far less destructive than radiation or chemotherapy. As a vaccine, it is suitable for those for whom it provides a net benefit (elderly, obese and the immuno compromised). Like all treatments, it is not without its risks (which those on the mandate side never were able to acknowledge). The main criticism I have had for this invention has not been for the invention itself, but for the government that has attempted to obscure from the public an accurate risk / benefit profile.
Good post. Exactly correct.
I would agree a tiny bit, but what you forget is the media had its hands more than full with putting out the constant firestorms of conspiracy theories. The side effects are not that much different than other vaccines and the benefits far far outweighed the risks, saving millions of lives. So that's the message when you only have so much time and dealing with the public.
Pretty hilarious that Karikó was unceremonious shown the door at Penn for presumed meaningless work; and they mocked her when she said she was joining BioNTech… and now they claim affiliation for her prize.
Obama knew that his Peace Prize, awarded by a different institute, was premature. The context of the time was that the Bush administration had pushed multiple wars, torture, and lawlessness for 8 years before he took office. Bush had divided Europe and there was a civil war raging in Iraq (hundreds of thousands of Iraqis had died already from the invasion and civil war) and worse in Afghanistan. So, when Obama came in, he reset the relations between the U.S. and Europe and peace, rather than war, was on the agenda. The Arab Spring prompted hopes of widespread democratization with the loss of support to the old dictatorships and oligarchies. Many of these hopes didn't pan out but we didn't start any new wars and he wrapped up the Iraq war.
Somewhat accurate. George W Bush really screwed up with his weapons of mass destruction and prelude to an unwinnable war in Iraq that further destabilized the region, whatever the intent (plus billions down the drain).
But, one Barack Obama essentially did the same thing in Libya under a different pretext. No Congressional approval, European support and troops already orchestrated, decapitate the regime. Now Libya is in a decade long civil war and massive instability that led to the recent massive flooding and death toll in the thousands, perhaps tens of thousands that could’ve been abated with a functioning government. But, hey, these are merely Libyan lives right, as long as we didn’t sacrifice American troops!?
I would agree a tiny bit, but what you forget is the media had its hands more than full with putting out the constant firestorms of conspiracy theories. The side effects are not that much different than other vaccines and the benefits far far outweighed the risks, saving millions of lives. So that's the message when you only have so much time and dealing with the public.
Covidicy and joedirt are borderline antivaxxers.
By far the biggest direct application of immune-tolerant mRNA tech is infectious disease vaccines. It works and it’s easy.
Cancer vaccines or therapies are years or decades away. A lot of basic science still to solve.
No one has ever really got a cancer vaccine to work, aside from viral cancers. Cancers necessarily have to become immune invisible to proliferate.
It’s also hyper-personalized (each person needs tumor sequencing or TIL TCR sequencing and a cell product made) and the current trials cost millions per person.
Yes, but it’s a start. Many cancers (blood, lymphomas) are viral in origin too.
No one has ever really got a cancer vaccine to work, aside from viral cancers. Cancers necessarily have to become immune invisible to proliferate.
It’s also hyper-personalized (each person needs tumor sequencing or TIL TCR sequencing and a cell product made) and the current trials cost millions per person.
It’s not about a vaccine. It’s about delivering a targeted treatment to attack specific cancers based on their genetic makeup. That is the real hope for mRNA.
I would agree a tiny bit, but what you forget is the media had its hands more than full with putting out the constant firestorms of conspiracy theories. The side effects are not that much different than other vaccines and the benefits far far outweighed the risks, saving millions of lives. So that's the message when you only have so much time and dealing with the public.
Covidicy and joedirt are borderline antivaxxers.
By far the biggest direct application of immune-tolerant mRNA tech is infectious disease vaccines. It works and it’s easy.
And it’s “borderline” unnecessary for cohorts outside of the ones JoeDirt already specified, which I never had an issue with. Not to mention the adverse event profiles not fully captured by the “official data,” which is very much variable depending on the country publishing it. We are all living proof.
Again, the CDC published that three vaccines PLUS Covid were marginally better against hospitalization and death than NO vaccines plus Covid. Better yes but not hugely so with the advent of Omicron. Stratified by healthy versus vulnerable groups, I bet the difference was within the margin of error.
Anecdotal observational data is data. I don’t know that many people, but I literally know three who died suddenly, two confirmed cardiac episodes, one who died from a botched exploratory surgery in the wake of a vaccine-induced decline, and now a pilot friend with an abnormal EKG. No one I know who refused the vaccines (all reasonably young and healthy) and who implemented reasonable at home protocols got terribly sick. The only two people in my family who got really sick were my thrice vaxxed mother who then treated w Paxlovid and has a lingering cough from hell a year later and my unvaccinated but 80-year old uncle, who was hospitalized but managed ok and has no lingering issues.
The only people I know now still getting Covid are all vaccinated, which confirms the sparse data out there that suggests a class switch IgG4 immune tolerance mechanism after the booster or immune imprinting. I know you are smart 2600bro, I know we probably have the equivalent education, but nothing you post will change my mind.
There were hundreds of thousands of people who SHOULD’VE been vaccinated who died or developed long Covid, but there were also hundreds of thousands who could’ve been saved had hospitals and medical authorities been allowed to practice some “unorthodox” medicine based on their training for viral, inflammatory, and thrombotic disease. They were shunned. Sad.
JoeDirt and I aren’t “anti-vaxxers” or even anti-mRNA platform for certain indications. I know the potential value here. We are just mRNA Covid vaccine skeptics.
No one has ever really got a cancer vaccine to work, aside from viral cancers. Cancers necessarily have to become immune invisible to proliferate.
It’s also hyper-personalized (each person needs tumor sequencing or TIL TCR sequencing and a cell product made) and the current trials cost millions per person.
It’s not about a vaccine. It’s about delivering a targeted treatment to attack specific cancers based on their genetic makeup. That is the real hope for mRNA.
Sure there hope for any form of nucleic acid driven therapy in cancer but the giant wall blocking progress is the delivery problem. And it’s a massive problem.
What makes mRNA so amenable to vaccines is you don’t need to deliver it site specifically. The adaptive immune system is evolved to deal with a threat anyway and turn it into a systemic memory response.