FG-4592 (ASP1517) the new wonder of endurance sport

I have to add! It has shown no major side effects like gw1516 and it is more effective. Even safer to take than EPO as no blood thickening or pressure issues. I think this is the next big thing.

I bet there are some 'enterprising' athletes who have already got their hands on some

I hope this doesn't become popular. The EPO Golden Age of Track and Field is a lot easier to type than The FG-4592 (ASP1517) Golden Age of Track and Field

It creates a constant supply of red blood cells. Does that mean it can beat the Biological passport?

There are no wonder drugs in sport. Your body is amazing. Why can't you understand?

oh please...... wrote:

There are no wonder drugs in sport. Your body is amazing. Why can't you understand?

tell that to rashid ramzi and lance dopestrong

If true, they won't be able to ban it eventually because everyone will take it. Not just athletes, everyone. Certainly the age of enhancement is just beginning.

The real fun will be when we can download to ourselves like Neo did in The Matrix. Suddenly a little HIF stabilizer is Neanderthal status. I'm excited.

oh please...... wrote:

There are no wonder drugs in sport. Your body is amazing. Why can't you understand?

What does this even mean? You don't believe that drugs work?

Skip demats wrote:

It creates a constant supply of red blood cells. Does that mean it can beat the Biological passport?

The supply is no more constant than what you get from taking EPO, so no.

EPO increases red blood cell count, and therefore, hematocrit. Thus, it makes the blood "thicker."

This results in the same effect: more red blood cells per unit blood volume. Therefore, "thicker" blood is also a potential negative side effect of this drug.

The Stache wrote:

EPO increases red blood cell count, and therefore, hematocrit. Thus, it makes the blood "thicker."

This results in the same effect: more red blood cells per unit blood volume. Therefore, "thicker" blood is also a potential negative side effect of this drug.

Not true in this case. As a HF stabiliser and a gene trigger. It actually just turns on EPO supply as the haemocrit level is dropping. It basically keeps your haemocrit from dropping during hard efforts. Even EPO cannot do this.

A bunch of blowhards pretending to be drug experts. Best of LetsRun right here.

is it rupp-certified?

Lewandowski wrote:

A bunch of blowhards pretending to be drug experts. Best of LetsRun right here.

The thing is, if you actually read the op links and had any idea of medicine or usage. You wouldn't be so quick to dismiss this drug or my knowledge.

While I may not be fully qualified haemotologist. I have studied psychopharmacology and I understand the power of genetic medicine. I got into medicine after years of being a pro-cyclist and doper(cheater). I saw how powerful these drugs were and it inspired me to study and use them in a positive way to help other people.

You can't imagine the feeling EPO gives you the first time you take it. The power you can create is on another level. The first time you take it, your body has this incredible pulsing feeling flowing through it.

Chris froome be on this!

Treads for wrote:

I got into medicine after years of being a pro-cyclist and doper(cheater). I saw how powerful these drugs were and it inspired me to study and use them in a positive way to help other people.

You can't imagine the feeling EPO gives you the first time you take it. The power you can create is on another level. The first time you take it, your body has this incredible pulsing feeling flowing through it.

If this is true, post your name and start giving more details. I think most people on letsrun would be more interested in that than a potential future drug.

Treads for wrote:

Lewandowski wrote:

A bunch of blowhards pretending to be drug experts. Best of LetsRun right here.

The thing is, if you actually read the op links and had any idea of medicine or usage. You wouldn't be so quick to dismiss this drug or my knowledge.

While I may not be fully qualified haemotologist. I have studied psychopharmacology and I understand the power of genetic medicine. I got into medicine after years of being a pro-cyclist and doper(cheater). I saw how powerful these drugs were and it inspired me to study and use them in a positive way to help other people.

You can't imagine the feeling EPO gives you the first time you take it. The power you can create is on another level. The first time you take it, your body has this incredible pulsing feeling flowing through it.

Well, without being an expert, you might still think a few surprising claims were made here. Increasing haemoglobin without thickening the blood? Preventing a haemoglobin drop during effort? (EPO acts very slowly, it takes about two weeks to reach the peak when moving to altitude, for instance. When you took EPO, did you get the effects in the next hour? How could this product make mature red cells appear in minutes?) A natural thing? (It is by definition artificial. Artificial EPO is very much like natural EPO and acts by letting the body `naturally' react to it and produce `natural' erythrocytes. But who would call this natural?)

During mountain stages of the Tour de France you’ll often hear Phil Liggett use the term “oxygen debt” – when the muscles lack an adequate amount of oxygen due to high-intensity anaerobic efforts. Oxygen debt is more formally known as hypoxemia.

The most important mediators of the cellular response to hypoxia are “transcription factors” (proteins which influence which genes are used in which cell) called HIFs (or hypoxia-inducible factors).

HIF activates the genes that influence adaptive responses to hypoxia, including:

– the production of EPO

– the way the cells generate energy

– the creation of veins and blood vessels (called VEGF: vascular endothelial growth factor)

– the supply of iron (important for red cell production).

From this list, it is clear that the HIFs have the potential to improve the performance of an athlete. Does that mean administering HIFs will have an immediate effect on performance?

The short answer is no, because the HIFs are targeted for degradation in the absence of sustained blood hypoxia, so providing an external source isn’t the best way to increase their activity. Instead HIF stabilisers can be used to prolong the activity of the HIFs and provide ongoing production of natural EPO when there is no biological need for it (i.e. when oxygen levels are normal in the blood).

HIF stabilisers

As mentioned above, HIFs also stimulate the formation of new blood vessels (a process called angiogenesis) and therefore HIF stabilisers will improve this process. For an endurance athlete, this means more blood vessels supplying the muscle, which are normally generated over time in response to training.

By using HIF stabilisers, an athlete may be able to decrease the training period required to improve the blood supply to the muscles from weeks or months to a matter of days. Think about this: More oxygen-rich blood being delivered to more blood vessels generated within new muscle tissue. Add to this an improvement in carbohydrate metabolism and you have a very attractive performance-enhancing drug. You can quickly see the consequences (or benefits) here.

HIF stabilisers are still being developed for routine use in humans but they are being tested in clinical trials now. These drugs are small chemical compounds that can be delivered in an oral pill and they are difficult to detect in blood and urine samples.

Lance? wrote:

Treads for wrote:

I got into medicine after years of being a pro-cyclist and doper(cheater). I saw how powerful these drugs were and it inspired me to study and use them in a positive way to help other people.

You can't imagine the feeling EPO gives you the first time you take it. The power you can create is on another level. The first time you take it, your body has this incredible pulsing feeling flowing through it.

If this is true, post your name and start giving more details. I think most people on letsrun would be more interested in that than a potential future drug.

Joe Papp?