I have used the hyperspeed 3s and 4s for all my road miles for the past year or two. I was alternating them with the NB MT100s when I was running more trails, but have been sticking to the roads lately so use them for pretty much all my miles now...
I am usually somewhere between 50-70 mpw, but focus mainly on marathons so do not do much high intensity stuff.
I usually get a new pair after 500 miles or so, but current pair are quite a bit over that now... the outsole is indeed pretty worn down on the forefoot, but they are still holding up...