What fun! The old, Marxism has never really been tried before. In all of these cases, a self-selected group of intellectual vanguards ushered in a revolution that led to the death and suffering of millions. Any political ideology that accords a select group of people special access to the truth, whether that's the proletariat, queers, or the special intellectual class that is supposed to ignite the working class revolution (see Gramsci), will wind end in an abusive power grab. Historical materialism is a deflection. All of these ideas flow from Hegel by way of Marx. It doesn't matter that Marx claimed to be secular, he created an anti-Enlightenment religion.
More to the point here, the idea that a person can somehow have an opposite sex essence is a religious/spiritual belief. It has no basis in reality, and it comes from radical social constructionist idealogues like John Money and queer theorists (most of whom are very fond of Marxism and draw heavily on it). People with these beliefs are impervious to evidence and reason. They dismiss obvious patterns in nature (sexual reproduction), instead chasing around rare exceptions to rules in order to prop up their bizarre beliefs.
There is a logical/rational way of understanding variations in sex and sex-linked behaviors that doesn't entail evolution denial or discarding biological truths that every sane scientist and person can recognize.