It’s not about a vaccine. It’s about delivering a targeted treatment to attack specific cancers based on their genetic makeup. That is the real hope for mRNA.
Sure there hope for any form of nucleic acid driven therapy in cancer but the giant wall blocking progress is the delivery problem. And it’s a massive problem.
What makes mRNA so amenable to vaccines is you don’t need to deliver it site specifically. The adaptive immune system is evolved to deal with a threat anyway and turn it into a systemic memory response.
Nonsense, I’m not an antivaxxer, I’m just vehemently against this vaccine for extremely “scientific” (Biden bad, Fauci bad, Trump bad) reasons including this steaming pile of BS I made up on the spot. Checkmate Ms. Karikó, I simply know better than you.
It’s not about a vaccine. It’s about delivering a targeted treatment to attack specific cancers based on their genetic makeup. That is the real hope for mRNA.
Sure there hope for any form of nucleic acid driven therapy in cancer but the giant wall blocking progress is the delivery problem. And it’s a massive problem.
What makes mRNA so amenable to vaccines is you don’t need to deliver it site specifically. The adaptive immune system is evolved to deal with a threat anyway and turn it into a systemic memory response.
Targeted delivery is the point of SNALP tech. The mRNA vaccine tech works really well for vaccines because, as you say, site specific delivery isn't as important in that application as it is in cancer treatment, but targeted delivery is the goal. Varying the types of lipids and PEGylations in the bilayer is one way to target delivery, but it only offers coarse control. Ideally, the surfaces of the SNALPs would have specific proteins in them that recruit them to target cells. You could vary these proteins to hit whatever cell you wanted. Lots of people are working on this approach at the moment. The success of the covid vaccine shows that the SNALPs can fuse with cells and deliver mRNA payloads well - successful targeted delivery will yield an immensely powerful biological tool
The experimental mRNA gene therapy was released without any long term clinical trials (Safety Data to the layman). It does not prevent infection. It does not prevent transmission.
Oh, and it might kill you..........
The Pfizer COVID-19 vaccines first became available for mass vaccination in the United States on Dec. 14, 2020, followed by the Moderna vaccine a few days later. The Johnson & Johnson vaccine would not become available till Feb. 27, 2021. As soon as the earlier vaccines became distributed en masse, the total number of deaths per week for the rest of 2020 from all causes in the United States jumped from 63,000 to 84,000, which is a 32 percent increase, unlikely to be attributable to any other cause but the vaccines.
The experimental mRNA gene therapy was released without any long term clinical trials (Safety Data to the layman). It does not prevent infection. It does not prevent transmission.
Oh, and it might kill you..........
The Pfizer COVID-19 vaccines first became available for mass vaccination in the United States on Dec. 14, 2020, followed by the Moderna vaccine a few days later. The Johnson & Johnson vaccine would not become available till Feb. 27, 2021. As soon as the earlier vaccines became distributed en masse, the total number of deaths per week for the rest of 2020 from all causes in the United States jumped from 63,000 to 84,000, which is a 32 percent increase, unlikely to be attributable to any other cause but the vaccines.
By far the biggest direct application of immune-tolerant mRNA tech is infectious disease vaccines. It works and it’s easy.
Again, the CDC published that three vaccines PLUS Covid were marginally better against hospitalization and death than NO vaccines plus Covid. Better yes but not hugely so with the advent of Omicron. Stratified by healthy versus vulnerable groups, I bet the difference was within the margin of error.
This is a plausible argument for apparently healthy young adults refusing vaccination after having had a covid infection, although it's probably not ideal.
It is a poor argument for having refused the vaccine prior to having been infected as the metric suffers from survivorship bias.
Question for the COVIDBRO's.... ("I am quadruple boosted")
Given what you know now, would you advise perfectly healthy members of your family to take the C19 Jab?
Yes. The risk:benefit ratio is clear from all the data collected. No matter what the Epoch Times insists, those of us who can do basic math can see the answer.
There was a recent paper that showed that the vaccine hesitant were lower IQ than the rest of the population. Makes sense given their inability to do simple arithmetic.
Again, the CDC published that three vaccines PLUS Covid were marginally better against hospitalization and death than NO vaccines plus Covid. Better yes but not hugely so with the advent of Omicron. Stratified by healthy versus vulnerable groups, I bet the difference was within the margin of error.
This is a plausible argument for apparently healthy young adults refusing vaccination after having had a covid infection, although it's probably not ideal.
It is a poor argument for having refused the vaccine prior to having been infected as the metric suffers from survivorship bias.
All you have to do is survive a COVID infection unscathed, hope you don’t get cardiac or autoimmune issues down the road, and pray your respiratory function recovers quickly — then you can make the case that your immune response good (but still significantly worse breadth of recognition than the vaccines give). Wow! What a deal, where do I sign up?
Sure there hope for any form of nucleic acid driven therapy in cancer but the giant wall blocking progress is the delivery problem. And it’s a massive problem.
What makes mRNA so amenable to vaccines is you don’t need to deliver it site specifically. The adaptive immune system is evolved to deal with a threat anyway and turn it into a systemic memory response.
Targeted delivery is the point of SNALP tech. The mRNA vaccine tech works really well for vaccines because, as you say, site specific delivery isn't as important in that application as it is in cancer treatment, but targeted delivery is the goal. Varying the types of lipids and PEGylations in the bilayer is one way to target delivery, but it only offers coarse control. Ideally, the surfaces of the SNALPs would have specific proteins in them that recruit them to target cells. You could vary these proteins to hit whatever cell you wanted. Lots of people are working on this approach at the moment. The success of the covid vaccine shows that the SNALPs can fuse with cells and deliver mRNA payloads well - successful targeted delivery will yield an immensely powerful biological tool
Great post. Targeted LNPs with specificity is indeed the objective.
Again, the CDC published that three vaccines PLUS Covid were marginally better against hospitalization and death than NO vaccines plus Covid. Better yes but not hugely so with the advent of Omicron. Stratified by healthy versus vulnerable groups, I bet the difference was within the margin of error.
This is a plausible argument for apparently healthy young adults refusing vaccination after having had a covid infection, although it's probably not ideal.
It is a poor argument for having refused the vaccine prior to having been infected as the metric suffers from survivorship bias.
Only a minority weren’t convalescent prior to the full series of vaccines.
Again, you and I aren’t disagreeing that there were some cohorts who should’ve been vaccinated no matter what.
You gloss right over the millions of lives saved by the vaccine.
Btw, can you point me to the nobel prize for 10 g a day of quercetin (by suppository)?
You mad bro? Can you read? I didn’t gloss over anything. And it’s not political for me, though you have this incessant, borderline maniacal need to lump all mRNA vax skeptics in with M.A.G.A. Very weird.
We also could’ve saved millions of lives with proactive, allopathic treatment, not naturopathy, another sociopathic fixation of yours.
Sure there hope for any form of nucleic acid driven therapy in cancer but the giant wall blocking progress is the delivery problem. And it’s a massive problem.
What makes mRNA so amenable to vaccines is you don’t need to deliver it site specifically. The adaptive immune system is evolved to deal with a threat anyway and turn it into a systemic memory response.
Targeted delivery is the point of SNALP tech. The mRNA vaccine tech works really well for vaccines because, as you say, site specific delivery isn't as important in that application as it is in cancer treatment, but targeted delivery is the goal. Varying the types of lipids and PEGylations in the bilayer is one way to target delivery, but it only offers coarse control. Ideally, the surfaces of the SNALPs would have specific proteins in them that recruit them to target cells. You could vary these proteins to hit whatever cell you wanted. Lots of people are working on this approach at the moment. The success of the covid vaccine shows that the SNALPs can fuse with cells and deliver mRNA payloads well - successful targeted delivery will yield an immensely powerful biological tool
Sure, the best example is the in vivo CAR T paper (also from Penn, below) for targeting heart failure models in mice. Anti-CD5 fuses to LNPs with CAR mRNA. it works because targeting circulating cells with a highly type specific antibody is relatively easy (CD5 is great)
I am not confident the delivery problem will be solved anytime soon. People have been working on this for recombinant proteins,DNA, RNAi, TALENs, CRISPR/Cas systems… since the 80s. Both specificity and efficiency are still struggles for lots and lots of cell types. Solid tumor cancer is probably the worst system by far - poor vascular, reduce or no immune infiltration, massive genomic and proteomic heterogeneity….
Hope I am wrong!
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