This thread was deleted by a volunteer moderator. I certainly don't want a thread this big deleted so I've restored. THat being said, this thread has served it's purpose. I've closed it to new posts.
We have a new 2024 vaccine thread here. New people don't need to try to wade through 20,000 posts to figure out what is going on.
Linked post above comes from NY Times newsletter from a couple days ago noting a higher year to date Covid death rate in white Americans vs minorities and attributes the switch to vaccination rates. Today's newsletter links a blog post from an epidemiologists that argues that the effect might better be explained by group age disparities. That is a Simpson's paradox issue as has been discussed ad nauseum in this thread. In any case the relative rates between the groups does seem to have shifted.
In the beginning of the pandemic, I wrote a lot of posts addressing and countering mis- and dis-information. I’ve largely stopped because I am, quite frankly, tired of fighting. As Jonathan Swift said, “A lie goes around the...
So the vitamin C works against sepsis theory is wrong.
In this trial of IV vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. #CCR22https://t.co/8tpW7Yud6apic.twitter.com/1Jf9aIka8Y
1) smaller, poorer quality RCTs not being useful for much beyond justifying a larger study. Just like with IVM, small, early, and less rigorous studies showed a possible effect. The obvious thing was to wait until we had big RCT data to form an opinion. Nobody here is going to rabidly defend vitamin C for sepsis now that we have conclusive data. Or maybe they will?
2) “It can’t hurt” is often tragically wrong. There was a statistically significant INCREASE in death or organ dysfunction in the vitamin C arm of the trial. Even something as commonplace as vitamin C can be harmful with the right dose and the wrong health background.
1) smaller, poorer quality RCTs not being useful for much beyond justifying a larger study. Just like with IVM, small, early, and less rigorous studies showed a possible effect. The obvious thing was to wait until we had big RCT data to form an opinion. Nobody here is going to rabidly defend vitamin C for sepsis now that we have conclusive data. Or maybe they will?
2) “It can’t hurt” is often tragically wrong. There was a statistically significant INCREASE in death or organ dysfunction in the vitamin C arm of the trial. Even something as commonplace as vitamin C can be harmful with the right dose and the wrong health background.
It's funny this thread has died because the all of anti-vaxxers conspiracy theories have flatten completely flat. The past few months were supposed to be "the proof," but the vaccines continue to be exceptionally effective at stopping people from dying.
It's funny this thread has died because the all of anti-vaxxers conspiracy theories have flatten completely flat. The past few months were supposed to be "the proof," but the vaccines continue to be exceptionally effective at stopping people from dying.
What is funny is that you "and" Harambe "both" stopped posting for 5 days, and now you are "both" back posting within minutes of each other.
It's funny this thread has died because the all of anti-vaxxers conspiracy theories have flatten completely flat. The past few months were supposed to be "the proof," but the vaccines continue to be exceptionally effective at stopping people from dying.
What is funny is that you "and" Harambe "both" stopped posting for 5 days, and now you are "both" back posting within minutes of each other.
Really funny...
Could it be, I am just overjoyed when Harambe choke-slams anti-vaxxers and, thus, cannot resist poasting when this thread returns to the front page.
1) smaller, poorer quality RCTs not being useful for much beyond justifying a larger study. Just like with IVM, small, early, and less rigorous studies showed a possible effect. The obvious thing was to wait until we had big RCT data to form an opinion. Nobody here is going to rabidly defend vitamin C for sepsis now that we have conclusive data. Or maybe they will?
2) “It can’t hurt” is often tragically wrong. There was a statistically significant INCREASE in death or organ dysfunction in the vitamin C arm of the trial. Even something as commonplace as vitamin C can be harmful with the right dose and the wrong health background.
Thanks for posting this, but my takeaway from the study is a bit different.
Let me give an analogy. If you drive a car that's low in oil for tens of thousands of miles, a lot of bad things can happen. If you wait until one of those bad thing happens (worn rings, for example), you can't bring the oil level up to normal and expect it to cure that bad thing.
These patients were VERY sick... and age 65±14. They were already in ICU before IVM was started. 40% died regardless of treatment. By six months, 46% and 43% of the vitC and control group had died. We don't know what the quality of life was during those last months of life.
Thus, this was a pretty narrow study. I agree that it proves that IV vitamin C in 1) the dosage used 2) after sepsis progressed to ICU admission 3) in an old patient with chronically low vit C levels isn't beneficial and might be worse than no action.
I'm not a strong proponent of IVM, but I am extremely disappointed with the hatchet job that IVM has been given by the media and medical researchers.
Here is my beef with IVM research.
In spite of the massive interest that IVM has generated, I have yet to see an IVM study that follows FLCCC protocol. Specifically, 1)Start IVM within 5 days of first symptom. 2) Continue for a minimum of 5 days or until symptoms are gone 3) given at the recommended doses and 4) Insure zinc levels are adequate or supplement as needed. This is where the observational studies have succeeded with IVM.
In every IVM study I've read, IVM is started too late, not continued for 5 days, not given in the dose recommended, and zinc levels have not been supplemented.
I'm a layman with no research background, yet I can find this protocol with a simple search.
Why isn't the recommended protocol being tested? I can't find a single IVM study that follows the protocol that front line doctors have used successfully.
Let me end with another analogy. In 1940, Howard Florey did his first human test of penicillin on Albert Alexander, who had sepsis. The patient recovered, but after five days, penicillin treatment stopped because Florey ran out of penicillin. The patient relapsed and died. Florey accurately deduced that given sooner or given longer, penicillin would have been successful. I'm not suggesting that vit C would have cured these patients. I'm pointing out that researchers setting up IVM studies, for some unknown reason, lack the ability to learn from medical history. Florey "observed" what worked... and millions of lives were saved.
IVM *might* be a decent therapy. It might not. Doctors should be allowed to prescribe it until we find out. We can just agree to disagree on that point.
This would be more interesting if we could know what percentage of the relevant age group(s) in that area had been vaccinated/boosted. Random-number example: If 90% have been vaccinated and boosted, but the unvaccinated 10% constitute a quarter or more of those hospitalized/intubated, we could--if the population is large enough--reasonably conclude that the vaccines were helpful.
I don't know the numbers of vaccinated/boosted in MI, but I know that in NYC only 2% of residents over age 18 are completely unvaccinated. So if the unvaccinated in a given age group constitute something larger than 2%, especially something significantly larger, it's reasonable to conclude that vaccination may confer a major benefit.
Fortunately, we have good data for recent trends in NYC. As of 5/21 (data are incomplete for more recent weeks), the weekly age-adjusted death rate per 100,000 for those who are vaccinated and boosted was .25; for those who were vaccinated but not boosted, .41; and for those not vaccinated, 12.24--nearly 49 times the rate for those who were vaccinated and boosted.
NOTE that we should not necessarily give the vaccines and boosters *all* the credit, as those who have not been vaccinated are more likely--on average--to have other behaviors/conditions that would predispose toward bad outcomes.