Evan Jager "likely doping" per new Fancy Bears leak

jagers said his test was on feb 9th in park city 2016, yet we see from his instagram that he was having coffee at a cafe in flagstaff the next day, feb 10th.

https://www.instagram.com/p/BBnwwX_HtbZ/?taken-by=evanjager

blood values being changed by altitude is a good excuse but he should have made sure that his "story" checked out.

lets see what jager and all his fanboys have to say to this.

Comments:

1) This is a worksheet for further testing, but it takes an "atypical" result to even get on this list, and the limits are large, because there is a desire to limit false positives. Then 3 experts have to agree with an opinion that is unanimous... 2 times...for there to finally be an anti-doping rule violation.

2) There are no actual hemoglobin, reticulocyte, and OFF scores (e.g. Ms. Paula Radcliffe having a very large magnitude 21.88% increase in her hemoglobin values from 12.8 g/dL to 15.6 g/dL in a very short duration time period of only 2 days, between Oct. 2 and Oct. 4, 2003. The only plausible explanation is an autologous blood transfusion by Ms. Paula Radcliffe.)

3) In this chart, the columns are blank for the people (e.g Dzmitry Marshin, Lisa Nemec) who have been banned for an anti-doping rule violation, because there are no more steps in terms of further testing to be done.

4) There are some very fast runners on the list.

Sifan Hassan- 3:56 1500m, Meseret Defar -14:12 5k, Silas Kiplagat-3:27 1500m, Asbel Kiprop 3:26 1500m, Mary Keitany 2:17:01 marathon, Matthew Kisorio (58:46 half marathon, banned for nandrolone in 2012, was managed by Federico Rosa, coached by Claudio Berardelli), Geoffrey Mutai- 2:03 marathoner and 2:05 at NYC.. and there is a comment about Geoffrey Mutai having a high reticulocyte % 2x on his recent blood tests, with a question about if he has been tested for an ESA (erythropoiesis-stimulating agent such as EPO, Hypoxia-Inducible Factor stabilizers such as FG-4592, and/or inhalation of the noble gases xenon or krypton, which can increase endogenous EPO levels.)

5) Evan Jager is the only runner on the list with a +++++ priority. The chart shows that there is a lot of testing planned for Evan.

6) Mo Farah's latest sample on the chart now puts him in the 'normal' category...but the headline here at LetsRun.com and this thread says that Sir Mo is..."LIKELY DOPING."

7) Wrong again LetsRun.com.

(This is not a big surprise.)

8) Galen Rupp...is always on ALL lists that are leaked.

(This is not a big surprise.)

9) Who is not on the list?

Shannon Rowbury is not on the list.

Jenny Simpson is not on the list.

The total number of female runners from the USA on the list...is ZERO.

10) Centro is not on the list.

11) Dathan Ritzenhein is not on the list.

12) Eliud Kipchoge is not on the list.

13) Kenenisa Bekele is not on the list.

14) Jo Pavey is not on the list.

15) Laura Muir is not on the list.

On the follow-up status for Jager it notes "test ESA/4 to 2 weeks before next Comp." I would assume they're suspecting an ESA over any blood transfusions?

And reference to the HIFs, i.e., FG-4592, there's been one (maybe two?) drug positives to date. In this particular study it references a cyclist, who was the first athlete to test positive. Interestingly, the study reports that FG-4592 doesn't show any profound alterations to the ABP either during use or after:

It's crazy that there is a double standard as everyone jumps to Jager's defense. Sorry they didn't know who he was when the put "Likely Doping", because he is likely doping.

An ITALIAN CYCLIST tested positive for FG-4592.

http://www.cyclingnews.com/news/taborre-positive-for-novel-epo-stimulating-drug-fg-4592/

Is this a big surprise?

No.

The company FibroGen has phase 3 compounds FG-2216, FG-4592, and FG-4497, which stabilize HIF-1alpha by inhibiting the enzyme prolyl-hydroxylase, which is involved in the breakdown of HIF by the ubiquitin proteosome pathway. HIF is a transcription factor which increases the gene expression of about 200 different genes, including the gene for EPO.

Increased levels of HIF-1alpha signals cells in the kidney to increase transcription of erythropoietin (EPO), which travels to the bone marrow, binds to progenitor cells, and increases erythropoiesis, which is the production of new red blood cells. This is the mechanism of action of HIF stabilizers. It is also the mechanism of action of living at high altitude (hypoxia), which also inhibits HIF-prolyl-hydroxylase to stabilize HIF-1alpha and increase endogenous EPO production, which then increases the production of RBCs containing hemoglobin. Each gram of hemoglobin binds 1.39mL of oxygen. Hemoglobin carries nearly 20mL of oxygen per 100mL of whole blood.

Another compound is cobalt chloride, which also acts to stabilize HIF, is orally active, but is not recommended, as it is toxic to the gastrointestinal system, thyroid, heart, liver and kidney. It may also cause cancer. There is now a blood test to test for cobalt levels.

Other recent research is looking at inhalation of the noble gases xenon and krypton, which are used as HIF activators to increase erythropoiesis. They have been used by Russian athletes. They have recently been banned and there are now tests for both noble gases.

For further reading, check out: Simon Beuck, et al. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis stimulating agents in current and preventive doping analysis. Drug Testing and Analysis 2012 Nov;4(11):830-45. This article is from their special issue named Sports Drug Testing for Erythropoiesis-Stimulating Agents and Autologous Blood Transfusion. There are many interesting articles in this issue.

https://www.ncbi.nlm.nih.gov/pubmed/22362605

https://www.ncbi.nlm.nih.gov/pubmed/26939898

https://www.ncbi.nlm.nih.gov/pubmed/24861600

There is now a test for the detection of the doping of racehorses with xenon and krypton noble gases...by humans.

https://www.ncbi.nlm.nih.gov/pubmed/27001214

This is not a big surprise for humans.

It never ends.

rjm33 wrote:

Other recent research is looking at inhalation of the noble gases xenon and krypton, which are used as HIF activators to increase erythropoiesis. They have been used by Russian athletes. They have recently been banned and there are now tests for both noble gases.

Wrong, they were banned years ago when there was no evidence at all they were effective.

I still remember USADA's tortured logic (posted it here) which boiled down to:

xenon is a gas

hydrogen sulfide is also a gas

inhaling hydrogen sulfide is dangerous

=> inhaling gases is dangerous

=> inhaling xenon is dangerous

=> to protect athletes, xenon banned (presumably all other gases too)

Anti-doping is a joke. Manipulating inhaled gases to atypical levels for effect on blood is precisely what altitude tents do. Why should people be allowed to use those instead of actually going to altitude?

Altitude tents just simulate altitude.

Mo Farah and other athletes train at 2000m altitude and sleep in an altitude tent simulating 3000m altitude.

Altitude tents are banned in Italy.

ha ha ha

That must of been very inconvenient for Dr. Michele Ferrari and the Italian cyclists.

What can an Italian cyclist do without an altitude tent?

In 2006, two years after his death, Pantani was linked to the Operación Puerto doping case. According to documentation released by Spanish radio network Cadena SER, Pantani was allegedly given the code name "PTNI" by Eufemiano Fuentes, with a detailed program in 2003, his last season, including EPO, growth hormone, Insulin, Levothroid and IGF-1. Italian newspaper Corriere della Sera indicated that he was administered over 40,000 units of EPO, seven doses of growth hormone, thirty doses of anabolic steroids and four doses of hormones used to treat menopause. In 2006 Jesús Manzano, a Spanish professional road racing cyclist whose statements led the Guardia Civil to conduct the Operación Puerto investigation, disclosed in an interview with French television channel France 3 that Pantani was a client of Eufemiano Fuentes.

Matt Rendell's biography of Pantani suggests Pantani used recombinant erythropoietin (rEPO) throughout his professional career. It alleges that seasonal hematocrit levels from several sources showed variations which exceeded those possible naturally. A French senate report into doping released in July 2013 confirmed that Pantani had tested positive for EPO during retroactive testing of samples from the 1998 Tour de France conducted in 2004.

Professional cyclists will try anything before athletes from other sports.

They are human lab rats.

Bad Wigins wrote:

rjm33 wrote:

Other recent research is looking at inhalation of the noble gases xenon and krypton, which are used as HIF activators to increase erythropoiesis. They have been used by Russian athletes. They have recently been banned and there are now tests for both noble gases.

Wrong, they were banned years ago when there was no evidence at all they were effective.

I still remember USADA's tortured logic (posted it here) which boiled down to:

xenon is a gas

hydrogen sulfide is also a gas

inhaling hydrogen sulfide is dangerous

=> inhaling gases is dangerous

=> inhaling xenon is dangerous

=> to protect athletes, xenon banned (presumably all other gases too)

Anti-doping is a joke. Manipulating inhaled gases to atypical levels for effect on blood is precisely what altitude tents do. Why should people be allowed to use those instead of actually going to altitude?

Didn't the Russians concoct a protocol using xenon gases? From what I gather it needs to be taken very close to the event which makes it visible for detection. (If they actually want to catch anybody....at all).

Interesting, rjm. Your posts are always packed with information, but sometimes I have trouble pulling out your bottom line conclusions. Are you saying that you think Jager is dirty based on this chart? If so, I'd be curious to hear your thinking. (I can't make much sense of the chart.)

It also sounds like you think that Mo comes out looking good, and that people not on the list at all are likely to be clean. Am I reading you right?

Honest questions -- no hidden agenda. I value your opinion and would be interested to hear what your hunches are and what you feel certain of.

I agree with you - the chart is confusing. What I don’t understand is a priority ranking for a "likely doping" classification, i.e., does a one-star mean that you are lesser "likely doping" than a higher, more nefarious 5-star ranking? It would seem the priority ranking would be appropriate for the suspicious category, where it would determine the level of suspicion and strategy for target testing & follow-up.

As I mentioned, a "likely doping" classification at face value sounds nefarious...how else can that be interpreted? And with that particulary classification what is the endpoint? Continual testing in hope of an eventual positive? And if that positive never comes, then what? Does the athlete get downgraded to suspicious indefinitely? I know the IAAf press release said an athlete can fluctuate between classifications, however, IMO, I think USADA is careless with the wording of "likely doping" if in reality it implies more of a suspicion that actually doping.

I do not have a conclusion. Everyone needs to come up with their own conclusions.

The chart is for further testing. It looks like the expert did not think that altitude explained the results, since there would not be so much focused testing in the future if the expert that looked at his scores thought that they could be simply explained by altitude There are no actual numbers for hemoglobin, reticulocyte %, or OFF scores. The chart is from April 2016. It showed more testing was planned for Evan Jager. I do not know the results of the testing from April 2016 to July 2017, so it is difficult to come to a conclusion.

It would be better to not be on the "atypical" result list, but it does not mean that he is "likely doping." Further testing could move him into the "normal" category. There has not been an ABP violation but it is very difficult to get an ABP violation.

Everyone sees what they want to see.

Mo is tested more than anyone else on that list. His latest sample moved him into the "normal" category, but the thread and headline at LetsRun.com says he is..."LIKELY DOPING."

That is not what the chart says. The chart says that Mo is now in the NORMAL category.

LetsRun.com is wrong again and sees what it wants to see.

Mo has had some other problems. For example, there was the incident with Dr. Chakraverty not recording in the medical records of Mo Farah anything about the intravenous L-carnitine infusion he administered to Mo Farah in April 2014 just before the London marathon...and the incident when Mo did not hear his doorbell when the doping control person was there for a doping test...and Sir Mo writing about knowing Jama Aden in his book...but then saying that he did not really know Jama Aden very well at all...and also a small problem with his name on another list:

http://www.ecestaticos.com/file/753ecfdec678bb9afa388efae5766386/1466790509.svg

Everyone sees what they want to see.

What do you see?

Alright then...in reality it's nothing more than a higher-level suspicious list. The "likely doping" classification/characterization is misused and simply means more target testing in "hope" of a positive. And since it's difficult to get a ABP sanction with all the defenses these athletes come up with these days, the strength of a positive A & B sample would probably have more weight in a CAS hearing (at least most of the time).

Why is Jager lying about his location?

doping sleuth wrote:

jagers said his test was on feb 9th in park city 2016, yet we see from his instagram that he was having coffee at a cafe in flagstaff the next day, feb 10th.

https://www.instagram.com/p/BBnwwX_HtbZ/?taken-by=evanjager

blood values being changed by altitude is a good excuse but he should have made sure that his "story" checked out.

lets see what jager and all his fanboys have to say to this.

Where did Jager say he was tested on Feb 9 in Park City?

In his statement he says that he has no records of being tested that day and does not remember being tested that day. Unless he mentioned it elsewhere, location was not stated.

From his statement:

I have gone through my records looking for the test results or test notification from February 9, 2016 (the date listed as my “last ABP test date”) and cannot find any notification of having taken a drug test on that day. I also was not contacted by USADA/WADA/IAAF regarding an abnormal blood panel test result. There is a possibility that I did take a test that day, but I have no record of it. I am trying to contact the authorities to determine if I was tested that day and how my name could have ended up on such a list

I think he says it in his interview with Letsrun linked on homepage.

in the latest letsrun podcast he said that is when it happened dude

Bump

Any athlete can check all their previous testing dates via the ADAMS system so all he needed to do is say 'ADAMS doesnt show a test for me that day'? O that it does. His statement sounds dodgy to me.

http://adams-docs.wada-ama.org/display/EN/My+Recent+Tests

1. Click the My recent tests link on the My zone page.

2. You will see a list of your most recent test entered in ADAMS, if any. Up to fifteen test entries will be listed in descending chronological order - the most recent ones being displayed first. Should there be more than fifteen test entries, click the view all button to see all of them.

Seems like these Titans never fell.