I tried low dose Retuditride on a whim to drop the last few pounds I wanted to lose (5'9" 145, and I wanted to be 135). It certainly worked well for losing the weight, but I would NEVER do it again! My resting HR went up 15bpm and I felt horrible all the time. My running became a torture. It took 8 weeks to get back to "normal", but my new normal was way slower than before. I looked fit and lean at 135, but I was anything but fit. I'm at 140 now 12 weeks after taking it, and my running is nearly back to where it was when I started. Perhaps I am an outlier with my bad reaction, but I really regretted trying it. I would far prefer to be hungry than to feel so rotten that I couldn't eat.