Aragon wrote:
If you can find studies to debunk the claims made by me, feel free to refer to them, PMC database is open 24/7.
The silence from casual obsever about the 1/6 ratio between delta-performance and delta-Vo2max is interesting, because I failed to see him pointing out even the obvious shortcoming in the papers.
About that rHuEPO induced training effect, I'd be interested if there is even speculation about it in the academic body of literature.
How about the conclusions of three (3) of the top IAAF anti-doping experts? I take it you never read the Zaripova CAS hearing?
Quick background: Zaripova was a Russian SC athlete (9:05) who won gold at both the WC at Daegu and the London Olympics. Hematological anomalies were detected in her ABP data and the medals were a stripped along with her PB annulled. Quite a blow to the Russians since the primary objective of their State-sponsored doping program is to win Olympic & WC medals.
CAS 2015/A/4006
Paragraph 49 (i):
49. The contents of the declarations of the experts can be summarised as follows.
"i. Professor Schumacher confirmed the opinion expressed in the Initial Review and in the Joint Expert Report and explained that EPO increases an athlete’s maximal oxygen uptake (the “VO2max”) by 1% to 4% for a period of up to 4 weeks after the erythropoiesis stimulation, depending on the dosage of its administration, and confirmed that the use of micro-doses over a longer period can produce long-lasting effects. At the same time, Professor Schumacher indicated that manipulation is possible to rapidly and significantly decrease the HGB values, by infusing plasma expander. Without manipulation, HGB values drop 6 to 10 days after the end of the stimulation phase. Professor Schumacher, then examined the Athlete’s ABP indicating, inter alia, that also samples 1 and 2 are not normal and that sample 6 shows a pattern of prolonged stimulation (in light of its values, inconsistent with a single administration), with sample 7, marked by a drop in RET%, marks a “suppression” phase. In the same way, according to Professor Schumacher, the
sequence shown by the Athlete’s blood values mentioned by Mr Scott in his opinion is not normal."
Paragraph 50:
"3. If the answer to question 2 in relation to sample 6 is ‘yes’, do you consider
that her blood doping out-of-competition on 20 July 2011 is likely to have
assisted her training for or affected her performances in the subsequent
competitions in which she participated at the World Championships on 30
August 2011 and in the Diamond League on 16 September 2011?"
"VO2max is the maximal oxygen transport capacity, a measure of maximal endurance performance and the key physiological measure that is modified by EPO administration or blood transfusion through the increase of red blood cell mass. In the literature, several studies report the effect of EPO treatment on VO2max several weeks after cessation of treatment …: … the increase in VO2max is still significant 3 weeks after treatment. … the improvement is still significant 4 weeks after treatment. … the increase in VO2max per gram of increase in haemoglobin concentration is 20 ml of O2 per gram increase in Haemoglobin and that the results are similar to those observed after the transfusion of red blood cells. These findings were confirmed …. In summary, the effect of blood manipulation on VO2max, depends on the relative increase of haemoglobin concentration. Relating these facts to the profile, it is obvious that the athlete was training with the beneficial effects of an increased red cell mass and thus a higher VO2max in the lead up to the competitions in August and September 2011: Sample 6 clearly displayed a stimulated erythropoiesis (see
previous paragraph and our initial review), meaning that red cell mass was increasing already. An increased red cell mass will have allowed her higher running speeds in training and thus greater training stimuli. Previous research has also shown that the effects of performance enhancing substances might influence the ability of the body to respond to new training impulses long after the use of such substances …. Although the impact of EPO on the ability to cope with training has
not been scientifically examined until present, the available body of literature … on non-haematological action of EPO underlines the high likelihood for a positive contribution”.
"In other words, the Appellant underlines that “it is the unanimous opinion of the IAAF experts in this regard that it is highly likely that Ms Zaripova’s blood doping on 20 July 2011 assisted her training for and participation in both the World Championships in Daegu on 26 August 2011 … and the Diamond League meeting in Brussels on 16 September 2011”.
https://jurisprudence.tas-cas.org/Shared%20Documents/4006.pdf