Generally speaking:
NXN: Pro = Better field of athletes, Con = worse weather
Brooks: Pro = Better weather, Con = worse field of athletes
Though I suppose it could be debatable whether the caliber of the field is actually a pro or a con (maybe you're just happy to travel to a national meet with a better chance to finish in the top half of the field).
For a comparison of the fields, all NXR athletes are able to compete at all Brooks regionals aside from athletes in the Brooks West states (which has it's qualifier the same day as NXN) and Florida athletes (whose state meet was on the same day as NXR Southeast). It's notable that it used to only be Foot Locker Midwest and NXR South athletes that could do both (as you'll see, there isn't nearly as much overlap in other regions). This is how the Brooks qualifiers fared at their respective NXR meets:
Midwest: Boys = 2 NXN Qualifiers, 6 DNQ, 2 skipped NXR; Girls = 2 NXN Qualifiers, 6 DNQ, 2 skipped NXR
1 Calvin Seitz 11 Jasper, IN 15:11.2 NXR MW DNS -- IN State #1
2 Lucas Tanner 12 De Forest, WI 15:16.9 NXR HL #6 (Qual)
3 Kamari Ronfeldt 11 Ann Arbor, MI 15:24.4 NXR MW #3 (Qual)
4 Wyatt Dann 10 Larkspur, CO 15:24.6 NXR SW #19 (DNQ)
5 Alex Roberts 12 Overland Park, KS 15:25.6 NXR HL #7 (DNQ)
6 Cadel Ruthven 12 Fort Collins, CO 15:27.6 NXR SW #22 (DNQ)
7 Gabriel Voelker 12 Peculiar, MO 15:29.5 NXR MW DNS -- MO State #4
8 Lucas Wik 12 Boulder, CO 15:29.9 NXR SW #47 (DNQ)
9 Jaden Merrick 12 Cedar Falls, IA 15:30.1 NXR HL #10 (DNQ)
10 Rocco Culpepper 12 Lafayette, CO 15:33.4 NXR SW #31 (DNQ)
1 Sophia Szolosi 12 Athens, OH 17:22.9 NXR MW DNS -- OH State #1
2 Emma Hoffman 12 Plainwell, MI 17:30.8 NXR MW #2 (Qual)
3 Maddie Gullickson 12 Minneapolis, MN 17:33.8 NXR HL #1 (Qual)
4 Elena Aldrink 12 Powell, OH 17:35.5 NXR MW #8 (DNQ)
5 Libby Dowty 12 Morgantown, IN 17:46.6 NXR MW #17 (DNQ)
6 Julia Score 12 Noblesville, IN 17:58.1 NXR MW #18 (DNQ)
7 Daphne Weller 10 Fort Wayne, IN 17:58.5 NXR MW #10 (DNQ)
8 Payton Meineke 12 Thornton, CO 18:00.2 NXR SW #11 (DNQ)
9 Annabel Pollert 11 Carmel, IN 18:00.8 NXR MW #22 (DNQ)
10 Emilia Garces 10 Midland, MI 18:01.6 NXR MW DNS -- MI State #6
Northeast: Boys = 1 NXN Qualifier, 4 DNQ, 5 DNS; Girls = 1 NXN Qualifier, 1 DNQ, 8 DNS
1 Samuel Laverdiere 12 Litchfield ME 14:59.9 NXR NE DNS -- New England DNS
2 Nathan Lee 12 Greenwich CT 15:00.0 NXR NE #46 (DNQ)
3 Nicholas Mazzeo 12 Narberth PA 15:03.2 NXR NE DNS -- PA State #2
4 Travis Furmanski 12 Lebanon PA 15:19.6 NXR NE #9 (DNQ)
5 Sam Leone 12 East Lyme CT 15:20.1 NXR NE DNS -- New England #10
6 Benjamin Berman 12 New York NY 15:20.6 NXR NY #2 (Qual)
7 Teddy Hojlo 11 Greenwich CT 15:23.7 NXR NE #19 (DNQ)
8 Michael Fritz 12 Wilkes Barre PA 15:24.2 NXR NE DNS -- PA State #7
9 Tycen LaBelle 11 Preston CT 15:29.2 NXR NE DNS -- New England #3
10 Charlie Palmore 12 Washington DC 15:31.8 NXR SE #115 (DNQ)
1 Abigail Hennessy 12 Westford MA 16:47.3 NXR NE DNS -- MA MOC #1
2 Virginia Kraus 12 Bethlehem PA 17:01.1 NXR NE DNS -- PA State #1
3 Leah Starkey 10 Ocean NJ 17:02.6 NXR NE DNS -- NJ MOC #1
4 Amelia Avila 11 Olney MD 17:04.1 NXR SE #4 (Qual)
5 Allison Lee 12 Princeton NJ 17:20.7 NXR NE DNS -- NJ MOC #7
6 Alexis Paterna 11 Exeter NH 17:25.8 NXR NE DNS -- New England #2
7 Ana Bondy 12 Carlisle PA 17:31.2 NXR NE DNS -- PA State #5
8 Chase Gilbert 12 Old Lyme CT 17:32.0 NXR NE DNS -- New England #4
9 Molly Domurat 12 Stockton NJ 17:33.5 NXR NE DNS -- NJ MOC #8
10 Lexie Cole 11 Port Jefferson Station NY 17:34.2 NXR NY #7 (DNQ)
South: Boys = 2 NXN Qualifiers, 3 DNQ, 3 DNS and Florida #3/5; Girls = 2 NXN Qualifiers, 5 DNQ, 2 DNS and Florida #2
1 Evan Spreitzer 12 Melbourne FL 14:52.13 FL State #3
2 Kavi Gibson 12 Durham NC 14:52.81 NXR SE DNS -- NCI State #1
3 Noah Strohman 12 Wichita Falls TX 14:57.37 NXR SO #8 (Qual)
4 Ryder Strohman 12 Wichita Falls TX 14:58.39 NXR SO #40 (DNQ)
5 Paul Van Laningham 12 Burlington KY 14:59.34 NXR SE #3 (Qual)
6 Ethan Garza 11 Helotes TX 15:00.12 NXR SO #13 (DNQ)
7 Myles Jermyn 12 Hillsborough NC 15:00.76 NXR SE #6 (DNQ)
8 George Lawson 12 Winston Salem NC 15:02.03 NXR SE DNS -- NCI State #4
9 Preston Sangely 12 Boca Raton FL 15:02.48 FL State #5
10 Malachi Burnett 12 Canton GA 15:05.70 NXR SE DNS -- GA State #10
1 Maysen Fletcher 10 Elkview WV 17:02.87 NXR SE #11 (DNQ)
2 Madison Muller 10 Sarasota FL 17:05.44 FL State #2
3 Calysta Garmer 12 Knoxville TN 17:05.96 NXR SE #2 (Qual)
4 Madeline Dorsch 10 Jackson Springs NC 17:06.15 NXR SE #3 (Qual)
5 Lilly Beshears 12 Springdale AR 17:10.61 NXR SO #9 (DNQ)
6 Carolina Areheart 12 Knoxville TN 17:13.54 NXR SE #20 (DNQ)
7 Jazzlyn Garmer 12 Knoxville TN 17:15.22 NXR SE #10 (DNQ)
8 Kaitlyn Estep 10 Cary NC 17:21.70 NXR SE #8 (DNQ)
9 Kasey Dingman 12 Mooresville NC 17:22.56 NXR SE DNS -- NCHS State #9
10 Sofi Alexander 12 Asheville NC 17:31.78 NXR SE DNS -- NCHS State #5