Exercise-in-a-pill boosts athletic endurance by 70 percent

end of running wrote:

This looks serious. I am going to miss racing.

https://medicalxpress.com/news/2017-05-exercise-in-a-pill-boosts-athletic-percent.html

Interesting, thanks for the link.

Carcinogenic

Oh...just wonderful news.

It won't be long before a sub-2 hr marathon is common.

It won't be long before sub-elites will progress to elite status at an alarming rate.

It won't be long until Senior/Grand Master's will be running times comparable to elites.

This whole concept of "Exercise-in-a-pill" gives me gas 😦

Carcinogenic, life span is very short after use (guaranteed less than five years because of rapid cancer growth throughout body), side effects may result in problems in appetite and recovery (this is not proven, but similar substances/drugs tend to have these effects), and comparing mice and men may have different effects because of evolutionary differences.

Sounds like a TUE for diabetic athletes

GW501516 does cause many different types of cancer in the mice.

The trials delivered some success but when high-doses of the drug were linked with increased rates of cancer in animals, GSK decided to scrap further development of the drug for humans. To quote a GSK representative, “toxicities were found in routine, long-term animal studies that were being conducted in parallel with the clinical studies.”

Or, to quote an article in New Scientist “tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb.”

https://cyclingtips.com/2013/04/the-new-epo-gw1516-aicar-and-their-use-in-cycling/

GW501516 has been used since 2009 by cyclists.

A Russian cyclist tested positive for GW501516 in 2013.

This is not a big surprise.

The other study in the article above on GW501516 used sedentary mice.

Look at what happens when AICAR (an AMPK activator) is used with a different PPAR-delta agonist (GW0742) in combination with exercise training in mice. The increase in running time to exhaustion was 355% in the sedentary group and 138-179% in the exercised groups, respectively.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823600/

rjm33 wrote:

GW501516 has been used since 2009 by cyclists.

A Russian cyclist tested positive for GW501516 in 2013.

This is not a big surprise.

Except it is really. Despite knowing of all the cheating in pro sports, I'm still surprised at the willingness of people to die for a 'win'. Or the willingness of organisations to sacrifice athletes, perhaps.

Thanks for the info.

...it doesn't work on East Africans, so says some coach out there...

I've heard of people using this stuff (GW501516 aka cardarine) as well as something newer called SR9009 aka stenabolic, but ethics aside, are they really all that effective in comparison to something like EPO? Definitely don't seem like they'd be worth the health risks.

It'll be banned, weather or not athletes can microdose it I don't know. But there have not been many human trials yet (if any).

notadoper wrote:

I've heard of people using this stuff (GW501516 aka cardarine) as well as something newer called SR9009 aka stenabolic, but ethics aside, are they really all that effective in comparison to something like EPO? Definitely don't seem like they'd be worth the health risks.

There's been one positive in athletics for GW501516 to date; a Russian racewalker - Elena Lashmanova. Maybe it's some kind of souped-up endurance booster that makes rocket fuel look mellow, as she's won every event she's competed in and at one time held the 20k WR:

Reading the science on this, though, it's been shown to cause neoplastic changes in the animal trials, and some forms of GW501516 could be detected for approx. 40 days after the intake of a single oral dose of 15 mg.

Both GW and sr9009 work extremely well and do not cause cancer in humans. If you look at the rat study where they did get cancer they were giving them 100 times the dose. Also you have to understand that the larger that mammal the less of the substance we need. Meaning if we took as much as the regular dosed Rats took that would be a very high dose for a human. And might really screw up something like a moose or an elk. The higher the body mass the lower dosage needed.

So with all of that said, we will as humans never take what they were giving the high dose group of rats or anyting close to it, not even in proportion to some of these athletes taking higher doses then some gym rats take. Also I can tell you from personal experience I know many many many men who have used both and the results are nothing short of amazing and the stuff definitely does work. When GW first came out I got my hands on a little and did a little research with my saber-tooth spider monkey and boy did it help him a lot. Sr was just as good with endurance and also seemed to help with recomposition and slight muscle hardness / very slight gains. But again this is all just for research purposes and entertainment purposes. Nothing I say should be taken as evidence as I'm not a doctor or any kind of medical professional.

One of my main points is that these athletes won't be getting cancer like the rats did. You guys have to do your homework and read the studies correctly. But let's go ahead and say that they did, as long as they did win the race if you went and ask them on their Deathbed I bet you money they would say they wouldn't change a thing because that is exactly what several other athletes that have had complications due to drugs have said. They would rather win and died or almost die then have never had that victory.

First of all, this drug is openly on sale at dozens of different 'research chemical' sites. I know for a fact that these websites, which make $$$$$$ a year from selling these things, pay people to go in forums to talk about how amazing the benefits are and how the dangers are overstated. I'm not saying Chemjr is such a shill, he is registered but his choice of name does ring a disturbing bell.

This drug caused the lab mice taking it to rapidly develop multiple cancerous tumors. This is the reason why Glaxo stopped trials, despite it being effective and a miracle endurance drug that might make EPO look like creatine (and therefore make Glaxo billions). No further safety tests on the drug have been peformed.

Anyone who takes this is an idiot.

You can get order this in the UK and have it delivered to your door, quite legally, within a week. When I look at Park Run results, I'm wondering now what percentage of the Masters runners with sub 20 minute times are taking this (and God knows what else)?

So which dying athletes have said this?

+1

Is a sub 20 as a Master really a red flag for doping suspicion?

I am honored to be included in this group.

Actually with a sub 18 at near 50 the suspicions must be off the charts.

I second this, those times are nowhere near low enough to be suspicious.

Before I begin, I should say that the tips that I told are not for use, it's only for the familiarization and nothing else. The pills that are described here probably can help but I can say that it's a lot better to raise the lvl of the muscles only with workouts and nothing else, because this is the most healthy way of getting stronger. When I was searching for the Stenabolic https://sarmguide.com/sr9009-stenabolic/ , I came across the tip that helped me. It can be used very carefully, using only micro dosages for the athletes that have problems with muscles. However, this product should be used carefully, so don't over with it.