No, just no.
I slogged through the book waiting for everything to tie together. For all the different story lines to intersect and maybe some of them reach a resolution. For the end of the book to tie in with the beginning of the book. For the side plots and long footnotes to taper off as we got to the meat of the action. But nothing of that sort. Barely anything happened. And as the book was reaching its conclusion, still going off on tangential stories not really related to the various subplots at all.
Perhaps I am less than enthused because we do live a drug-addicted and entertainment-addicted society today, which we use to escape from various ills. Our government and society nearly as cartoonish today as depicted in the novel. Maybe those elements of the novel don't have the same force as they did back in the 1990s.
Yes, DFW is a genius and Infinite Jest is a literary behemoth and perhaps worthy of its own encyclopedia. It is an impressive piece of literature. But as for doing what a novel is supposed to do, which is tell a story and entertain the reader? No, just no. It was a slog. I don't want to read novels that are slogs all the way through. Maybe it will come together more for me if I read it again but I don't want to dedicate the time.