+1
This affirms and expands on the post I made earlier in this thread.
The above defines running economy as "speed you can attain while at a specific Vo2".
However, as was touched on, there are factors aside from physiological composition or cardiovascular fitness contributing to running economy.
It is easier to simply characterize running economy as "efficiency of effort" for a given running pace. In absolute terms, but also in comparative terms, to others, and to one's self over time.
Running Economy (relative to pace) isn't particularly linear for a given individual at a given time - subtle form flaws incur increasing energy cost as maximal pace is approached, and conversely, a runner efficient at six-minute miles may find themselves struggling and comparatively inefficient trying to run nine-minute miles.
Form adaptations, form and pace adjustments, flexibility, strength, injury, fatigue, and even mental toughness/intelligence are examples of non-environmental factors affecting running economy. These vary over time, but also during an exercise bout, and can be consciously or subconscious.
Consciously, for example, one might intentionally adjust stride rate to compensate for hilly terrain or to recover from a tactical surge. Consciously, while running, you need to remember to lift your head, drop and relax your arms, or apply controlled breathing techniques.
Subconsciously, late in an effort, form may uncontrollably deteriorate.
As an example of training adaptation improving running economy, protracted periods of higher mileage lead to subconscious form adjustments; shortened stride, more rapid turnover, and reduced bounce - wasted motion is meted out through repetition and strengthening.