Xvbnnnbb wrote:
Good discussion. Just to be clear...
1. That burning sensation which forces us to slow down is caused by an accumulation of waste products (hydrogen ions etc...) that lower the pH? And this metabolic reaction is called anaerobic glycolysis?
2. Then why do physiologists use markers such as mmol of lactate?
3. I’ve heard others say that 4 mmol of lactate is some kind of threshold?
4. I understand that lactate is used as fuel and is not the enemy per say but why do we measure it in the lab?
5. Also, do 150m strides really cause acidosis? For me, 300m strides build tolerance and it FEELS much harder. But I was surprised to read from coachB that something as short as 150m could be presenting that kind of stimulus.
1. All carbohydrate metabolism starts with anaerobic glycolysis. This produces a net gain of 2 ATP. If there is enough oxygen present, the pyruvate produced from glycolysis will be converted into two molecules of acetyl CoA and taken into the mitochondrion where it will produce a truckload of ATP.
If there is not enough oxygen present in the muscle to convert all of the pyruvate to acetyl CoA, some of that pyruvate will be converted to lactate. This is done in order to free up NAD+ molecules (which are consumed during glycolysis). This process is called anaerobic fermentation and is what actually produces lactate. Same process that makes yogurt taste sour.
Lactate can then disassociate (lose a hydrogen ion). It is the disassociation of lactate that produces the drop in muscle pH (calling it acidosis isn't really correct, because pH drops, if I remember correctly, from 7.4 to 7.2 or so). If I don't have the numbers right, it's been a while since grad school.
2. mmol of lactate is a standard marker of muscular fatigue because as work rate increases, so does blood lactate. To be clear, the body is always producing lactate, but at rest or low exercise intensities, that lactate is converted back to pyruvate to be used as a fuel. As work rate increases, there is less oxygen available to convert the lactate back to pyruvate, so it begins to build up and tissue pH begins to drop.
3. The 4 mmol "threshold" is kind of arbitrary. When work rate (running speed in our case) increases at a linear rate, there will be a break point where blood lactate begins to accumulate at a non linear rate (i.e., even though running speed is increasing at a constant rate, blood lactate will suddenly begin to increase at a far faster rate). For many people this happens at around a running speed that will produce a blood lactate level of around 4 mmol/dL. (I think deciliter is the right unit here). So, coaches will use the 4 mmol standard as the "lactate threshold", or more specifically OBLA (onset of blood lactate accumulation).
4. Blood lactate is a relatively easy to measure marker of fatigue, see the last paragraph of point #1.
5. Any work where a muscle is being asked to produce ATP at a rate higher than it can do aerobically will produce a small amount of acidosis. I'm thinking of a girl that I had a few years ago who was a 2:29 800m runner. Early in the pre season, we were doing 150 @ 27 seconds (a little bit faster than PR pace) and she was feeling them. As she got fitter and fitter, we extended the time she could run at that pace. Eventually, she was doing 500s at 90 seconds (2:24 pace). She ended up running 2:25 that year. Think of doing anaerobic work as inoculating the body to decreased pH levels. If your body is already inoculated so that 300m at 800m pace is not stressful, then you wouldn't get a ton of benefit from 150s (unless you did a bunch of them with short rest). For a kid who maybe isn't super fit, 150 might be enough.