real answer: no one knows because almost no one has tried it.
anyone who has tried it will be doubted, etc.
I did it. after 5 years of college running ranging from 70-90 miles per week most weeks...I began taking one day off per week in my last yr of college. First year out of college I struggled, but ran ok - a little less mileage but with some cross training added in.
2nd year out of college things really started turning. Pr'ed just about every race for 9 months. Ran 4 days per week about 40 miles per week. Light cross-training on the off days (for me that was rowing mostly but only about 10 minutes fairly hard). stretching and light weights.
sun - longer day after a race: 10 miles at 6:00 pace very controlled pace
Tues - long tempo up to 12 miles but fairly quick 5:20-5:30 sometimes faster
Thur - pre-meet day: 6 miles total short tempo with 1 fast mile all out
Sat - race
my 8k went from 25:30 to 23:45. problem for me was after experiencing such amazing results from high quality low volume training - didn't go back to base building but instead tried to hammer out 10 milers at 5:30 pace and never got back to that level. Reason 1) no base Reason 2) starting out each season too fast trying to replicate what I did the year before vs. just running for feel. Too many runner now days try to run based on some formula or % of HR that someone else tells them they should be able to hit. The only person who can tell you how hard to run and how you feel is you. The best runners don't follow form charts - they follow their gut (their breathing)...if is controlled then the pace is right.
the exercise scientist have not invented the best training plans - they have simply looked at what those who have ran fast did and tired to explain why it worked. There is no right way to train. Be your own experimenter - that's the only way you will find what works best for you...