I’ve done Pfitz’s program (with a few modifications) for three marathons and have had good success with it....three marathons, three pr’s...2:30, 2:28, 2:26.
That being said, I think the MP runs have been the most important workouts I’ve done during training. I took his 12 week more than 70 mpw and added roughly 20% on the MP days, and 10% on the threshold days. I don’t think you can beat replicating the exact pace of your goal. I would also add a mile at the start and a mile at the end of MP on medium-long days and would also throw in a couple of miles of it on the sunday long run.... all to reinforce on what it feel like on race day. I was hitting MP during runs three days a week consistently for probably 7-8 weeks of the entire plan.
Thinking about what I did in my training in previous marathons, I'd always be worried about pace, constantly checking splits, or going with a faster group just because "it felt right."
I attribute a large part of hitting close to my goal in these last three races to “feeling pace” right away as a result of the MP workouts....they helped me lock in for 22 miles (the wheels did fall off a bit after that)....................as a side not doing a 16 ml MP run 5-weeks out was a tremendous confidence builder going into my last race. More than you wanted to know, and absolutely no science to back it up, but I believe MP is the key workout.