Repeat 400s at mile pace are most productive if you use rest periods which are about 1.5 times as long as the run periods. This is even more effective if you are jogging for a portion of the recovery periods. You will have lower blood lactate and higher muscle lactate using this format (as opposed to taking longer rest periods), but this is preferable for work done at this pace.
To promote relaxation and develop familiarity with the speeds involved, use shorter distances (usually between 100 and 200 meters) during the preseason and take sufficient recovery so as to remain comfortable and in complete control on these short reps. The variety this provides will break the monotony of your usual slower-paced, higher mileage running in the preseason, and it may also help prevent injury. Once you are comfortable running these short distances at mile race pace or faster, which should in no way be lactate intensive, you should have no trouble running 8 to 10 400s at mile pace with jogs of 1.5 times the run periods as recovery.
You can occasionally use moderate- to high-volume sessions with bouts as long as one minute each during the preseason (e.g., 10-20 x 1 minute "on" / 1-2 minutes "off"), but avoid any tying up, stuggling or form breakdown. The feeling at the end of each bout should mimic that of a strong tempo run, not that of an intense mid-season track session.