Hey, I'm torn. I'm looking to break 32 in a 10k road race two weeks from now in Pittsburgh. I have the Mayflys which I don't like for that distance and I have my Mach 7 xc spikes from college. If I removed the spikes is it do able? I love their feel.
If you're talking about the Great Race, I wouldn't do it because it's all downhill and your legs could really take a beating. That said, if you're not too injury prone and you really like the spikes, I guess you could try. Also, check out this year's update to the series, the Mach 9--it has an even better fit.
Have you run in them on the roads and also done more than just races and hard runs in them? You should do a couple of test runs on roads (easy runs or pick ups). If the course is downhills (as mentioned above) you should find some good, long downhill stretches.
Personally, I train and race in cross country flats (Puma Cortlandt XC flats). I've done several half marathons and a full marathon in them with no problems. I don't know anything about the actual spike plate on the Mach's, but if they aren't too slick on the roads and you're comfortable in them (~on the roads), go for it.