How many miles per week is VDOT (Jack Daniels) designed for?

Wear super shoes and your legs will be fine

To me, VDOT training is more about R, I, and T paces & volumes. I think E can be ignored completely. So yes, I think someone running 100+ mpw can still do VDOT training with great success (you probably have an actual coach at that point though). Daniels outlines the % of weekly volume with high end caps for the workouts, so I think it's manageable regardless of your weekly mileage.

Just finished my first JD training block(12 weeks) for HM. I have never averaged much more than 30-35mpw since I started running 6 years ago (I’m 41).

His plan had me at 45-55mpw with easy pace of 7:06-7:47 and that always felt comfortable. Never felt like I was pushing an easy run. That being said, if I was upwards of 80-90mpw that opinion may totally change.

Most people run easy pace way too fast. I see vdot easy pace more as a speed limit than a pace you must run.

My plan alternated between 65 mi and 58 mi per week. I believe they used your prior weekly running mileage when you sign up for a plan to get these numbers. I took my easy runs very easy and rarely worried about staying in the pace range that my VDOT score suggested. For example, if my E pace is supposed to be 7:20, then I made sure I didn't get too close to that pace for too long. I would often run easy paces of 8:00 or even 9:00. There were 3 easy days in the week. This allowed me to make sure my legs weren't shot when it came time for the workouts (2-3 workouts a week). I was still exhausted and beat up heading into my race, but sticking to the plan helped me jump from a 2:57 PR to 2:41.

As far as mileage is concerned, I will say that anyone I've known who was coached by him in person at Cortland State or just as a recreational runner were always surprised by the low volume of running he had them do and by the easy pace of the recovery runs.

Some college kids told me that they did less mileage in college than in high school.

That said, I don't know what it would be if he were coaching an elite, pro runner.

I'm slower than you so take with a grain of salt, but I considered JD paces were most accurate if you base your times on a longer event, especially if you are on a high mileage block. Since your 4:15 is equivalent to a 2:20 marathon, it would suggest similar times or both performances. I think average the 2:20 thon guy would have an easier time clicking 6:30s on an 80mpw schedule than the average 4:15 guy. A lot of those 4:15 milers are young talented guys who don't run much more than 40 mpw anyway and bounce back from workouts right away. Besides all that there is a difference between conversational easy pace and recovery pace