Living in the South I have to say that it is a big disadvantage. There's a reason distance runners flock to the West. The biggest enclaves of runners have always been, Eugene, Bolder, SD, Flagstaff... Sure you can the brief success of Shorter et al with the Florida Track Club in the 70's, but that's it.
Dealing with the Summer heat in the South isn't so much about one run, it's the constant every freakin day grind that wears you out. Sure you can hydrate hydrate hydrate, but that doesn't mean the run is cool, or enjoyable, it just means you don't die. Just doing a normal 6M run can you leave you so drained, so "done" that recovery is difficult.
Any time I vacation out West in the Summer and I get to run, I always think "Man, no wonder so many people talk about doing 100mpw like it's not that big of a deal." When you can knock out a morning 8M at 60 degrees with low low humidity you can finish that and still feel like a functional human.