Cool new paper showing that a previously little-studied metabolite, Lac-Phe, is strongly induced upon hard exercise (but not low-intensity or weightlifting) in racehorses, mice, and humans.
Exogenous Lac-Phe treatment suppresses appetite post exercise and leads to weight loss when obese mice are put on an exercise regime. Thus, Lac-Phe seems important for exercise-induced weight loss.
Here's the paper:
Here's a good summary:
Lac-Phe sounds like the name of one of my Vietnam childhood friends.
But to the point, this does purport to provide an explanation for what many of us have experienced.
Hdier wrote:
Lac-Phe sounds like the name of one of my Vietnam childhood friends.
But to the point, this does purport to provide an explanation for what many of us have experienced.
Yeah -- there have been runs where I'm starving after and some where I feel nauseous at the thought of food. Never though it was correlated with intensity but... maybe it was? Obviously plenty of other hunger signaling pathways contributing lots of noise.
sick of these woke runners 'hunger signaling.'
Sorry, dad humor. But for real, this was really insightful. I've always had a 30-45 minute window where the thought of food sickened me. Then I become ravenous.
