OK, let's be more pragmatic, and forget the unrealistic 600 week preparation phase study. Let's remove all the barriers -- I've grown since then, and I think I'm ready and willing to look at any and all objective evidence dispassionately. I'm open to any realistic alternative(s) which addresses the doubts I've expressed. Let's summarise one here, by taking a closer look at this term "effective".If you want to make a claim about the magnitude of effectiveness EPO can bring in a competitive racing setting, such as a "doped Ramzi" versus a hypothetical "clean Ramzi", or "Sumgong gained 9 minutes with EPO" or "3-6% performance improvement for "well-trained" subjects means 3-6% for elites", you basically need a reliable way to accurately determine two values: a best "clean" value, and a best "doped" value. Contrary to your suggestion that "clinical trials and real world evidence all line up to show that EPO is effective", neither "clinical trials", nor real world examples give us these two values we need to conclude EPO's effectiveness at bringing athletes to a higher performance level than could be achieved "clean".Studies typically show that EPO is effective at developing a higher performance level in a short-term fixed-length timeframe. These typically don't attempt to bring the control subjects to their "clean" potential, and therefore don't allow you to conclude that EPO is effective at changing your potential to an unnaturally higher level. We would need a study designed to answer: does EPO just bring you to your clean potential faster? or does it change your potential? That is, if a group of 9 minute runners can run 8 minutes in six weeks with EPO, or 8 minutes in six months "clean", is EPO "effective"? Now you might say it's not fair to train the control group longer, but in a real race setting, like the Olympics or World Championships, the training timeframe is not static for all competitors. And it's just for illustration to help us understand what we mean by "effective" in studies, and in the real world.In an attempt to be pragmatic, and maintain within existing ethics boundaries, simply performing follow-up experiments with the same subjects would bring new information, whether the initial observed trend continues, diminishes, or eventually converges.
Mr. Obvious wrote:
You've stated that for you to accept the results of a study it would have to involve the runners being in a 600 week pre-experiment controlled training phase.
This is clearly ridiculous and puts the lie to any idea that you are actually willing to look dispassionately at any evidence at all.
No, real world examples do not give as clear and unambiguous of evidence as clinical trials do. However the clinical trials and real world evidence all line up to show that EPO is effective.
You have yet to produce any evidence at all to contradict that.