So I read through this publication. Actually I remember seeing it years back, oddly enough, when I was looking this stuff up myself.Indeed the study is legit so far as I can tell. I would have liked to have seen more functional determinants of disease/health added. For instance what about all the other complications that are serious and associated with VZV such as Guillain-Barre syndrome, Strep infections, Bell's Palsy, meningitis or encephalitis etc. These are actual functional things that would be of interest to me, as the reason one would want to get a shingles vaccine, would be to prevent these serious complications that are said to be caused by this virus.So the study isn't a bad one, but in my opinion it doesn't tell me a whole lot about if these people are healthier because of the vaccine.When we see flu/cold (rhinovirus or influenza virus) clinical trials, we often never get functional definitions of effects of the vaccine either. We just get "did it create antibodies" or "did we see virus in the blood after vaccination?"Often times you vaccinate someone and almost always they will present with antibodies in what are determined to be "adequate" amounts for that person to be labeled "immunized." But then the study stops short of actually following the people around to see if they actually get the flu, or the cold.And so those trials claim 95% efficacy (because about 95% of people who get the vaccine, produce adequate antibodies). So the assumption of course is that these people will not get the flu or the cold. However, when that added criterion is considered, the value of vaccination is no better than placebo. That is, those who get the vaccine are just as likely as those who do not get the vaccine, so develop a cold/flu.Now, this study is a bit different because they followed the people for three years to document any illness. And it is statistically significant that less people presented with VZV dna if they were vaccinated against it. That's great, and this is where I take a HUGE left turn and pretty much become a "wacko" because I ask the question "how do we know VZV presence is a bad thing?" How do we know the virus is harmful and is a cause of disease rather than a result of disease.And this is where I lose most people, and the fact is, I'm still looking into this stuff everyday and I haven't found a conclusive answer either way. I know for sure that SOME viruses without a doubt are either totally benign (poliovirus, flu virus, HPV, Mad Cow "prions" and others) and results of disease, not causes. I also know that there are some viruses that do not even exist (HIV, HEP C) and are blamed for disease. And then there are others which I still am trying to figure out if they are true pathogens or not (chicken pox is one of those I am still unsure of).I would still suggest that taking a vaccine is almost surely more risky than living a healthy lifestyle, eating well and doing everything one needs to do for their body to be able to deal with any potential infectious threats, should there be any.Ultimately, its the individual's choice to do what they think is most safe. My problem with vaccines is that I think they are too simplistic in concept to account for the interaction and complexity of of immune system's interaction with our environment, AND, every time you take one, you take all kinds of other toxic crap you would otherwise never inject into you.I would basically require much more strong proof before I made a choice to vaccinate. And it would need to be quite convincing. A study like this doesn't do it for me. I wanna see functional elements of health and disease, I want to see the participants in the study, etc. I'm just extremely skeptical of this stuff because I know there is major incentive to promote the use of and advancement of vaccines.If we looked at the Tamiflu and Relenza studies that "proved" they were efficacious just around a year ago, we would have believed they were a good idea to take. But then when it was shown that the studies were flawed, and in fact fraudulent, it's a different story.I'm not saying this study is fraudulent, but I am saying I am always weary of studies done on things that I KNOW have major dollars attached to them.I'll trust an unbiased study about carpenter ant glucose metabolism, but I won't be so open to a study that proves a flu or herpes vaccine is worthwhile.Call me crazy. :-P
Mr Shingles wrote:
The emperor has taken off his clothes:
http://www.nejm.org/doi/pdf/10.1056/NEJMoa051016In a couple hours, I will post my analysis of this important document.