I've begun microdosing a GLP-1. It is incredible.

This world has become so lazy. Depending on pharmacuticals for weight loss. Electric bikes rather than pedal. Block printing because writing is too hard. AI for all the schoolwork. It's a wonder people can run without some type of assistance.

Electric bikes are wild. At least look cool and get a Vespa or motorcycle.

Talk to any ex-smoker and they gained at least 20 lbs when they quit. So many celebs still do it. Kate Middleton smokes, or at least she did until she announced her cancer.

You always need something in your mouth, not a joke.

yea, the fact that people celebrate no longer wanting/needing to eat anything, as if it's a good thing, is insane lmao

sounds like another "safe & effective"

helbocklaw.com

Ozempic Lawsuits Facing a $2 Billion Problem and Growing - Melinda J. Helbock, A.P.C. San Diego

Melinda Helbock, A.P.C.

Ozempic (semaglutide), a GLP-1 receptor agonist manufactured by Novo Nordisk, is now at the center of one of the largest pharmaceutical mass torts in recent history. With over 1,800 lawsuits already consolidated into federal...

Open link

In 10 , 20 years we'll have to watch old videos too remember what these morbidly obese folks look like. They'll go the way of Dodo birds.

I can't do the trendy super high carb thing but I can handle 50-60g per hour. I'm on the tirz.

No one knows because human testing has not been completed yet. Poster is recommending experimental compounds commonly sold grey-market as "research chemicals, not for human consumption" loophole.

It's probably better than tirz/sema in the short-term based on the results people are getting, and assuming no crazy side effects show up. No one knows anything more than that yet.

If you're ballsy enough to take grey market research chemicals, the one thing the poster is right about is that you better do your homework. How are you going to make sure that what you're getting is what you think you're getting and that it is made cleanly.

Personally I'm not willing to inject Temu-level quality controlled stuff, claiming to be a compound that hasn't passed human trials yet, into my body. If you want to though, you do you.

Edit: this is about retatrutide.

5mg is not "micro dosing". That's a standard therapeutic dose.

Absolutely do your research before you inject anything Into your body. I’ve only researched tesamorelin like I said it is FDA approved and you’re right most are in the grey market. I believe that will change in the next few years as it has with GLP-1s. Too much money to be made.

but I’ll say this again, proper nutrition and exercise trumps all of this, these are to aid in what you’re doing for optimal results.

I don’t see a problem with using drugs for weight loss.

Or for that matter with any of the other examples.

Despite the expected snarky comments, I appreciate your post.

After almost 50 years of running with knees and age slowing me down I have put on weight over the last few years. This was never an issue until around covid, working long hours and less aerobic effort. I consider myself very discipline but having trouble with getting the weight off. But as someone past 60 I also worry about losing much-needed muscle mass even if I were to micro-dose. Looking at getting total knee replacement to get more active and have been considering something like this to help with the well put "food noise" which was never an issue with high mileage.

Wish you the best.

I'm not a scientist or anything, this is just my personal experience and opinion.

A lot of the "side effects" of these drugs are simply side effects of rapid weight loss. We're seeing a lot more of them with the drugs because it's making weight loss attempts more successful. "Ozempic face/butt"? You've seen weight loss guys that had that long before Ozempic, they were just more rare. Weight loss has always been known to risk gall bladder disease which has a chance of cascading into pancreatitis.

With regard to muscle loss, I don't believe these drugs "cause muscle loss".

I believe they're being used by a lot of people to lose weight by lying on the couch all day and eating basically nothing. That strategy used to be very difficult to pull off without giving in to hunger, but it's as easy as can be with GLP-1. And of course it causes muscle loss.

I haven't lost significant muscle relative to fat, in fact my leg muscles (especially calves) are so oversized from carrying all the weight while ramping up running that people comment on them all the time (it's usually gym bros who look like they dry-scoop pre-workout), I can't buy pants that fit, and I perceive that they negatively effect my running economy.

But I eat >=3k calories per day, a decent amount of protein, and train consistently.

There are a lot of people who don't want you to take these drugs. Usually they're either holier-than-thou willpower bros (as seen earlier in this thread), or HAES advocates who feel threatened. Listen to a qualified doctor (not a bs online thing or wellness clinic) instead.

You don't have to take it for life; it's just a utility. The alternative is that you have to expend more mental bandwidth to plan your meals for the week, resisting random temptations, and eating your veggies and protein and fiber rich grains before anything else.

You would have a rebound of hunger for possibly a couple weeks after ceasing it, probably the extent of which is according to how long and how much GLP-1 drug was being taken.

You could stack a GLP-1 along with tesamorelin or ipamorelin to help maintain muscle with losing weight along with resistance training and incline walking for cardio(to prevent joint damage) until you reach your goals.

if you’re hurting with injuries or chronic pain you can research the Wolverine stack(TB500 + BPC-195) which many have said has healed their aches pains and injuries.

I'm on Retatrutide myself. So far it seems to be working great. Seeing about 2 lbs of weight loss a week with no effort involved. I'm M 40, about 35 lbs overweight. I fully expect to reach goal weight within 3-5 months on this. No side effects other than feeling nearly full all the time while on the medication. Its even hard to consume enough protein sometimes because I feel full quickly. Reta has 3 mechanisms of action that make it superior to semaglutide and tirzepitide, specifically the Glucagon component which raises your metabolism and helps the liver burn fat.

The future after Reta could be 'Bioglutide', the next drug that is a quadruple agonist with the 4th being an IGF-1 component to prevent muscle loss. Bodybuilders are already salivating over getting their hands on it. I'm assuming these 'grey area research companies' will get their hands on it first next year sometime. Anyways, like the OP, I am a fan of using these medications. They are not harmful and are actually incredibly beneficial beyond just weight loss.

After the initial weight loss, it can certainly help running. Here is an unrelated question, what about something like Athletic Nicotine? Heard the ad on a pod and it made no sense. Yet, I'm sure nicotine can help performance. Will athletes be tested for nicotine?

Thanks for your feedback, appreciate it.

There is a fair amount documentation that the GLP drugs can also result in muscle loss in addition to fat. I have talked with someone in this area of research and they are trying to make the targeting more selective but that's in the future.

While I agree that this should not impact active people like ourselves as much because we can workout to address the muscle loss, it is much harder for those over 60 because its also well documented that it is very hard after your 50's to put on additional muscle mass for a number of reasons. After seeing my father struggle in the last few years of his life with standing and walking in his early 90s, its something I wish I started addressing more seriously in my 40's and early 50's (more resistance training and less aerobic). So my concern is even with micro-dosing it might help me with my recent (5+ years) weight gain but have a penalty in muscle mass that might be hard to counter. I don't have an answer but thinking about going with some micro-dosing while I make a more concerted effort to hit the weights.

I think there were some studies on nicotine back in the 90s and it didn’t prove to be ergogenic. Way too addictive and risky to mess around with imho.

I’m intrigued by the use glp1 agonists in athletes. I’m a 40 year old midlife crisis hobby jogger, and despite a training volume of about 60-70 mpw (9-10 hrs), I have a ton of trouble keeping my bmi less than 22 since I get pretty ravenous during big training blocks. I’m not about to do it personally, but I could definitely see the appeal. Orthorexia doesn’t come naturally to all people.

An economist here. This has nothing to do with "macroeconomics" and, yes, paying for a drug out of pocket does not have much to do with insurance premiums