Israeli jogger wrote:
Haven't read the all thread.
rek you claim that EPO works only because people believe in it.
That logically may be true.
In fact if we replaced "belief" with "fairy dust" your argument would still be logically true, because fairy dust, just like belief, was never shown not to be the cause of the PE in PEDS.
Wouldn't it be reasonable to assume that a substance that has proven physiological changes that promote oxygen transport and utilization, is the cause ?
Can you purpose a mechanism by which EPO doesn't work?
Thanks for the serious question. Sorry for the length, but I hope it is clear.
First, I do not claim "that EPO works only because people believe in it".
I claim that EPO works, if and only if, there is a weakness, and EPO serves to strengthen that weakness. This can be physical and/or psychological.
I claim the motivation for deciding to take EPO is based on a belief that this is a necessary change to achieve further improvements that is not possible with legal methods.
The decision to dope, by virtue of breaking the rules, represents a major commitment to improved performance, which can result in physical causes from EPO, but also psychological causes, from the heightened commitment, and can be accompanied by other decisions, such as multiple doping products, training at altitude, e.g. to mask doping, dedicated training in a group, and other significant changes to training.
This makes anecdotal experience difficult to interpret.
I have no doubt that EPO physiologically causes the production of new red-blood cells, and I'm familiar with the proposed mechanism of increased oxygen transport, At the end, we measure best performances, and the unanswered question is whether EPO can cause a level of performances that are better than what can be achieved legally within WADA rules. Short term studies, showing gains over 4-12 weeks give us some clues, but do not indicate what is ultimately possible in the long term for any of the athletes in the study, nor elite athletes at that height of their fitness.
I'm not sure I can propose a mechanism where something doesn't work, but I'll explain:
If one trains at a high level for many years, any aerobic weakness diminishes with each year, as does the potential gain by attempting to make stronger something that is already strong. At some point, the potential gain becomes insignificant compared to the potential gains from other non-aerobic factors. This point where that occurs is unknown, and debatable.
Maximizing performance is not a question of maximizing one of the factors, but of optimizing all of the factors that produce performance. Think of it like comparing a high school band to a symphony orchestra. If you replace some the high school violinists with virtuosos, the performance is still a high school band. You need to develop all of the factors together in concert, and many of them are non-aerobic.
Earlier, I pasted a link of collected writings from exercise physiologist Stephen Seilers. In it he describes three waves of change:
1) Short term (roughly VO2max)
2) Medium term (roughly LT, AT, VT, and many other similar thresholds)
3) Long term -- efficiency/economy
The first two are aerobic, and max out relatively quickly. To become elite requires a mature development of the third non-aerobic factor.
We can see a great example of this recently with new Nike shoes, where it is the gains in efficiency that lead to observed performance improvements across all populations. Contrast this non-uniform gains in the EPO-era.