KMB, we are specifically discussing about EPO, not about generalized effects of doping.
I already wrote several times that, with the best possible training only, NEVER an athlete can reach the same level of muscle strength and explosivity, and this fact is well documented by the list of WR : no WR in throwing, few WR in jumping, and no WR for women in every event where the main physical quality is the muscle strength (practically any events but long distances) were established after 1988, when the antidoping became more effective vs/ steroids (Ben Johnson docet).
But blood doping is something else. While the increase of muscle strength is directly connected with the improvement of the performance in all the events where muscle strength has the main role, with EPO we have the increase of ability to transport Oxygen, and there is no real demonstration that this characteristic is ALWAYS connected with the increase in performance.
For example, many speak about VO2, but the importance of VO2 in middle distances is not fundamental. In other words, the best performances are not depending on the level of VO2, of course for goups of athletes with medium-high level of this value.
For example, the first athlete running Marathon under 2:10 (the Aussie Derek Clayton), had a VO2 under 70, which we can find in several athletes of medium level, and a lot of athletes with better VO2 never were able running so fast.
The final question is : which is the most important limiting factor for running fast long distances ? It's the transportation of Oxygen, or is some other factor ?
I think there is something else, more important of the ability to transport O2, and, looking at all the data I have (from Italian, Ukrainian, Kenyan, Ethiopian and Chinese runners), I think the limiting factor is in the ability to EXTRACT Oxygen from the air, rather than the ability to transport it.
This means that to increase over some level the ability to transport something that you don't have is obviously useless, and EPO doesn't increase the ability to extract O2 from the Air.