it's 2018 not 1998 wrote: The blood boosting/ped dogma is really saying that cell respiration can be enhanced with more red blood cells, implying that the human body doesn't produce enough for endurance races.
the bit I've set in italics is not correct, or at least misinterprets the facts.
the "PED dogma" as you call it, does not imply that the body does not produce enough red blood cells for endurance races. it implies that more oxygen is not a bad thing in an aerobic sport. the point is, that with literally every stride that you take while running you are destroying red blood cells. here is a quote from a paper describing the phenomenon...
"exercise can decrease the red blood cell mass by intravascular hemolysis mainly of senescent red blood cells, which is caused by mechanical rupture when red blood cells pass through capillaries in contracting muscles, and by compression of red cells e.g., in foot soles during running or in hand palms in weightlifters. Together, these adjustments cause a decrease in the average age of the population of circulating red blood cells in trained athletes."
there is also a phenomenon known as "sports anaemia," whereby highly-trained athletes have enhanced blood plasma volume which gives them, proportionately, a lower haematocrit. although it is called sports anaemia these folk are not anaemic in the classic sense, but they do have low haematocrit. additionally, since red blood cells are constantly exposed to high levels of oxygen and high concentrations of polyunsaturated fatty acids and haem iron, red blood cells also suffer from oxidative stress. since oxidative stress is proportional to oxygen uptake, it is also found that antioxidants in muscle, liver and red blood cells can also be depleted during exercise.
so, the reason blood doping works is that boosting red blood cell count increases the haemoglobin level, and this in turn improves the oxygen gradient at the blood lung barrier (because each haemoglobin carries four oxygen) which increases the oxygen carrying capacity of the blood, which improves the oxygen gradient at the blood cell barrier which increases the amount of oxygen available to a higher proportion of individual cells. this in turn also increases the CO2 gradient at the cell blood barrier increasing the level of CO2 removed from cells and carrying it back to the lung for expiration to the atmosphere. blood doping also reduces the average age of red blood cells and younger cells have improved oxygen release and deformability characteristics, both of which also improve tissue oxygen supply. and, by reducing the average age of red blood cells it also offsets the effects of oxidative stress, which normalises levels of antioxidants.
it's really just a matter of improving oxygen supply to tissues, improving CO2 exhaust, and correcting exercise induced antioxidant depletion. this is the exact opposite of your claim, "This is beyond bad science, it's weird cult belief." it is in fact very simple science easily understood by anyone sufficiently interested to read it with an open mind.
cheers.