bsishsdv wrote:
Listen to this podcast and/or read the articles cited.
"Andrew Huberman, neuroscientist and professor at Stanford University School of Medicine, takes it a step further, waiting 90 to 120 minutes (2 hours?!!) for his first cup of coffee, even though he’s “thinking about and fantasizing about and craving caffeine” the moment he wakes up.
“The reason I delay caffeine is that one of the factors that induces a sense of sleepiness is the build-up of adenosine in our system,” he said. "The buildup of adenosine accumulates the longer we’re awake, so early morning your adenosine levels are likely to be very low.
"However, caffeine is an adenosine blocker—actually a competitive antagonist, meaning it binds to the same receptors that adenosine does." That’s why you feel more alert after your cup of joe (and after your coffee nap), because the caffeine is essentially blocking the adenosine from adhering to its normal receptors.By delaying his caffeine 90 minutes to 2 hours after waking, Huberman wards off a late afternoon, or even early afternoon, crash after the caffeine wears off. And the delay allows for cortisol to follow its regular pattern."
His explanation seems a bit squirrely. I guess I'm not smart enough.