Big change in plans. Mile attempt no longer a consideration as I have a hunch some of the tumors in my abdomen are growing again, lots of crowding, and an inflammation marker was high. I've been having lots of symptoms the last month similar to when I was diagnosed with cancer back in 2010. Can't get in to see my oncologist until the 21st so I have to once again change my eating habits to accomodate food tying to move through a crowded abdomen. I am trying to keep my weight up with high calorie fats - olive oil, avocados, nuts and seeds, which also don't seem to take up as much space in my GI tract. More frequent small meals and something I didn't realize to do last time - exercise to slow down the muscle wasting (cachexia), although I may switch to an exercise bike or pool to burn less calories while still getting a cardiovascular workout.
The cardiovascular aspect to training while a tumor is growing is something I believe will eventually be found to have importance for cancer patients. If tumors grow without the influence of exercise, particularly when they may be aggressive and causing symptoms, tumors grow abnormal vasculature, which is a problem for good drug perfusion throughout a tumor. There is a researcher at Harvard, Rakeesh Jain, who studies tumor vasculature normalization but they use drugs to modify the vessels, which have side effects, another one is Peter Carmeliet at the University of Leuven, Belgium. However, Lee Jones at Duke did a study last year showing that exercise modified the vasculature of prostate tumors in mice towards normal, with a greatly improved blood flow. He is now doing a similar study in women with breast cancer.
Why may this be important? First, better drug perfusion throughout a tumor should make drugs more efficient. Second, it is quite common for patients to stop exercising when they are symptomatic, or at diagnosis (diagnosis shock), they don't feel well and are tired. I've been experiencing this the last month and my motivation is way down, and I understand all this stuff, so I understand why most patients do not exercise right around diagnosis. If they are symptomatic and the tumor is growing at a higher rate, then the tumor blood vessels are growing without any influence of exercise, which Dr. Jones' study is the first to show that exercise might wrest control of vessel growth away form the tumors, normalizing it.
Before some of you comment 'won't normalized blood vessels cause the tumor to grow more?' No, so far a few studies have show that normalized tumor vasculature does not increase tumor growth, in fact there is some evidence that metastasis and proliferation decrease.
So, if I find out on the 21st that I need more chemotherapy, I want my tumor(s) to be as well vascularized as possible for hopefully a better response to the drugs. Unfortunately, there are no studies yet to confirm all this. That is why we need funding at WorkOut Cancer to support studies of this type. Your donations matter, and it is exercise, something we're already in to.
Thanks!
Week of 1/7
Mon AM exercises & light stretching
PM 5 mile run on treadmill @ 1% grade, down to 6:24 last mile, felt awkward warming up. Weights.
Tue AM 5 miles on treadmill 0% grade, down to sub 6:40 pace, felt awkward warming up.
PM AT, stretching.
Wed PM massage, no run - stomach an issue.
Thur AT, 4 miles on treadmill 0% grade, down to sub 6:40 pace.
Fri AT, 4 miles on treadmill 0% grade, down to sub 7:00 pace. Weights.
Sat AM 4 miles on treadmill 0% grade, down to sub 6:40 pace.
PM stretching
Sun rest