This thread was deleted by a volunteer moderator. I certainly don't want a thread this big deleted so I've restored. THat being said, this thread has served it's purpose. I've closed it to new posts.
We have a new 2024 vaccine thread here. New people don't need to try to wade through 20,000 posts to figure out what is going on.
Christian Cabrera, 40, an unvaccinated comedian and father, tested positive for COVID-19 after Christmas, expressed his regret over not getting vaccinated a day before dying from the virus.
Let me explain to you how drugs are tested for safety. To be safe, drugs must do less harm than the benefit they are meant to provide. This is done by conducting a large, long duration, often 5 years, double blind, placebo controlled drug trial. Placebo control means that a group of test subject of equal size to other test groups must be give saline. Saline is used because it is known with certainty to not harm humans in any way. Double blind means that neither the doctors conducting the trial nor the test subjects can know if they are getting saline (placebo) or the drug being tested. Such a study has never been done for any vaccine. If you doubt me, post a link to the study. Otherwise, STFU and let the people that understand science do the talking.
Let me explain to you how drugs are tested for safety. To be safe, drugs must do less harm than the benefit they are meant to provide. This is done by conducting a large, long duration, often 5 years, double blind, placebo controlled drug trial. Placebo control means that a group of test subject of equal size to other test groups must be give saline. Saline is used because it is known with certainty to not harm humans in any way. Double blind means that neither the doctors conducting the trial nor the test subjects can know if they are getting saline (placebo) or the drug being tested. Such a study has never been done for any vaccine. If you doubt me, post a link to the study. Otherwise, STFU and let the people that understand science do the talking.
Injections were given 28 days apart, in the same arm, in a volume of 0.5 ml containing 100 μg of mRNA-1273 or saline placebo.
Designated team members within Moderna have unblinded access to the data, to facilitate interface with the regulatory agencies and the data and safety monitoring board; all other trial staff and participants remain unaware of the treatment assignments.
Vaccine dose preparation and administration were performed by pharmacists and vaccine administrators who were aware of treatment assignments but had no other role in the conduct of the trial. Once the injection was completed, only trial staff who were unaware of treatment assignments performed assessments and interacted with the participants. Access to the randomization code was strictly controlled at the pharmacy. The data and safety monitoring board reviewed efficacy data at the group level and unblinded safety data at the participant level.
Literally the first trial I found.
5 years definitely not a standard for trials. That's a number you made up.
This post was edited 14 seconds after it was posted.
Let me explain to you how drugs are tested for safety. To be safe, drugs must do less harm than the benefit they are meant to provide. This is done by conducting a large, long duration, often 5 years, double blind, placebo controlled drug trial. Placebo control means that a group of test subject of equal size to other test groups must be give saline. Saline is used because it is known with certainty to not harm humans in any way. Double blind means that neither the doctors conducting the trial nor the test subjects can know if they are getting saline (placebo) or the drug being tested. Such a study has never been done for any vaccine. If you doubt me, post a link to the study. Otherwise, STFU and let the people that understand science do the talking.
Injections were given 28 days apart, in the same arm, in a volume of 0.5 ml containing 100 μg of mRNA-1273 or saline placebo.
Designated team members within Moderna have unblinded access to the data, to facilitate interface with the regulatory agencies and the data and safety monitoring board; all other trial staff and participants remain unaware of the treatment assignments.
Vaccine dose preparation and administration were performed by pharmacists and vaccine administrators who were aware of treatment assignments but had no other role in the conduct of the trial. Once the injection was completed, only trial staff who were unaware of treatment assignments performed assessments and interacted with the participants. Access to the randomization code was strictly controlled at the pharmacy. The data and safety monitoring board reviewed efficacy data at the group level and unblinded safety data at the participant level.
Literally the first trial I found.
5 years definitely not a standard for trials. That's a number you made up.
Over 900 children were enrolled in a double-blind placebo-controlled clinical study of measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) trivalent vaccine. The trivalent vaccine caused about...
Let me explain to you how drugs are tested for safety. To be safe, drugs must do less harm than the benefit they are meant to provide. This is done by conducting a large, long duration, often 5 years, double blind, placebo controlled drug trial. Placebo control means that a group of test subject of equal size to other test groups must be give saline. Saline is used because it is known with certainty to not harm humans in any way. Double blind means that neither the doctors conducting the trial nor the test subjects can know if they are getting saline (placebo) or the drug being tested. Such a study has never been done for any vaccine. If you doubt me, post a link to the study. Otherwise, STFU and let the people that understand science do the talking.
Injections were given 28 days apart, in the same arm, in a volume of 0.5 ml containing 100 μg of mRNA-1273 or saline placebo.
Designated team members within Moderna have unblinded access to the data, to facilitate interface with the regulatory agencies and the data and safety monitoring board; all other trial staff and participants remain unaware of the treatment assignments.
Vaccine dose preparation and administration were performed by pharmacists and vaccine administrators who were aware of treatment assignments but had no other role in the conduct of the trial. Once the injection was completed, only trial staff who were unaware of treatment assignments performed assessments and interacted with the participants. Access to the randomization code was strictly controlled at the pharmacy. The data and safety monitoring board reviewed efficacy data at the group level and unblinded safety data at the participant level.
Literally the first trial I found.
5 years definitely not a standard for trials. That's a number you made up.
Not even 120 days. In actual science, to prove safety, the trial must be “long term”. Less than four months is not long-term and no other drug on the market has been approved for use in humans after such a short period with the possible exception of a few drugs that showed benefit in late stage terminal cancer patients. But even this is exceptionally. Vaccine don’t remotely fall into this category.
Let me explain to you how drugs are tested for safety. To be safe, drugs must do less harm than the benefit they are meant to provide. This is done by conducting a large, long duration, often 5 years, double blind, placebo controlled drug trial. Placebo control means that a group of test subject of equal size to other test groups must be give saline. Saline is used because it is known with certainty to not harm humans in any way. Double blind means that neither the doctors conducting the trial nor the test subjects can know if they are getting saline (placebo) or the drug being tested. Such a study has never been done for any vaccine. If you doubt me, post a link to the study. Otherwise, STFU and let the people that understand science do the talking.
Injections were given 28 days apart, in the same arm, in a volume of 0.5 ml containing 100 μg of mRNA-1273 or saline placebo.
Designated team members within Moderna have unblinded access to the data, to facilitate interface with the regulatory agencies and the data and safety monitoring board; all other trial staff and participants remain unaware of the treatment assignments.
Vaccine dose preparation and administration were performed by pharmacists and vaccine administrators who were aware of treatment assignments but had no other role in the conduct of the trial. Once the injection was completed, only trial staff who were unaware of treatment assignments performed assessments and interacted with the participants. Access to the randomization code was strictly controlled at the pharmacy. The data and safety monitoring board reviewed efficacy data at the group level and unblinded safety data at the participant level.
Literally the first trial I found.
5 years definitely not a standard for trials. That's a number you made up.
This study assesses factors associated with regulatory approval or reasons for failure of investigational therapeutics in phase 3 or pivotal trials and rates of publication of trial results.
We identified all new drugs, therapeutic biologics, and vaccines that entered phase 3 or other pivotal testing between January 1, 1998, and December 31, 2008, with follow-up through December 31, 2015. We excluded nontherapeutic products, such as diagnostic tests, as well as blood and blood component products. This study period was chosen to allow sufficient time for trial completion (typically 2-5 years), regulatory review (up to 1 year), and publication of trial results, resulting in a total of up to 7 years or more from the start of a phase 3 trial to final approval or discontinuation).
This is so easy. You guys are pathetic. You know nothing about science. 😂
Oops. Reading is hard. Next time try a video. Placebo was NOT saline in this study. Fail again. Should I check your third study? Can your ego hand another fail?
You are 0 for 4. This study does not even consider what was used as the placebo. Again, adjuvant and preservatives in saline is not the same as pure saline.
Those that think vaccines are unsafe have already identified the adjuvant and preservatives as likely source of negative health outcomes.
So where are we? Oh yah, back to STFU unless you can provide evidence of safety.
And the one study this paper cites is wrong. In the Gardasil-9 study Merck spiked the placebo with amorphous aluminum hydroxyphosphate sulfate, a neurotoxin.
We identified all new drugs, therapeutic biologics, and vaccines that entered phase 3 or other pivotal testing between January 1, 1998, and December 31, 2008, with follow-up through December 31, 2015. We excluded nontherapeutic products, such as diagnostic tests, as well as blood and blood component products. This study period was chosen to allow sufficient time for trial completion (typically 2-5 years), regulatory review (up to 1 year), and publication of trial results, resulting in a total of up to 7 years or more from the start of a phase 3 trial to final approval or discontinuation).
This is so easy. You guys are pathetic. You know nothing about science. 😂
You’re don’t understand the process. Very few Ph3 trials take 5 years. The vast majority are 1-3. The timing is not for long term safety profiling but a combo of factors:
1) enrollment, without a ton of resources like operator warp speed, enrollment can take a while
2) efficacy, lots of diseases require a while for efficacy measurements. COVID during a pandemic didnt … “do people get COVID”
3) regulatory hurdles within trials - cutting red tape for COVID really sped things up.
So you can see how we can get to a fully enrolled and studied Ph3 trial for a COVID vaccine in a year. It’s not that crazy. Remember the had EUA status for over 2 years while the FDA collected more data.
You are 0 for 4. This study does not even consider what was used as the placebo. Again, adjuvant and preservatives in saline is not the same as pure saline.
Those that think vaccines are unsafe have already identified the adjuvant and preservatives as likely source of negative health outcomes.
So where are we? Oh yah, back to STFU unless you can provide evidence of safety.
Ah you’re an adjuvant truther. Makes sense. Was wondering the spin you were gonna have.
You do know the point of including the immunostimulatory adjuvant as a control is to demonstrate that it’s an adaptive response from vaccination that prevents disease and not innate?
Good news. mRNA vaccines don’t need adjuvants! You must be excited, but you’ll surely find a way to discredit those trials too.