trashcan wrote:
peacefularson wrote:
and i didnt say he was only on fentanyl. the pills he took were a combination of fentanyl and methamphetamine.
The meth dose was sufficiently low it would have been from the day before, and if it was on board it would have counteracted the effects of the fentanyl to some degree. Also, oral absorption usually takes around 40-45 minutes. Mucosal absorption is usually faster, but apparently slows down a lot with large doses of fentanyl, so we are still in the 40 minute+ range. This means that (as not all life processes cease when the heart stops) his blood level in the ME’s office was probably far higher than it was when he was under Chauvin’s knee.
https://pubs.asahq.org/anesthesiology/article/88/2/305/36529/Dose-Proportionality-and-Pharmacokinetics-of-Oral
Hi, trashcan
I have skim read the article - interesting. Thanks for posting it and the other articles, but i think its not quite that clear.
The study does not appear designed to seriously investigate rate of increase of dose due to oral fentanyl; that appears to be a side effect. The dose rates were only measured every 15 minutes in the first hour, and the dose / time graphs are displayed in intervals of 300 minutes over a 1500 minutes period on the x axis. So the first hour interval (15) minute cannot give clear results (too grainy) and the graphs cant show the detail you use. If there is part of the article with better granularity and better x axis definition for the first hour, with faster intervals than 15 minutes, please tell me.
You can see that dose does rise really rapidly and appears to peak in maybe 40-45 minutes. It also drops rapidly. I believe that 'takes around 40-45 minutes' is very different from 'peaks' in 40-45 minutes.
The graphs dont seem to show a major change reduction in dose increase rate related to dose size, so why do you say that please?
Finally, and very importantly, the cdc paper i quoted earlier mentions the very fast transdermal properties of fentanyl (why it is commonly given in patch form), and the simple physical contact of the pill sliding down yer gullet into your stomach is meant to provide a very fast hit. Any applied physicist, such as me, or a level chemist will tell you that increase surface area rapidly speeds reactions. If GF had munched the pills, as i understand munched tabs were found, then the contact effects would have been greatly magnified.
I agree with you about the meth, that seems a red herring. Re blood levels increasing after death; there are so many unknowns there, i dont have a comment on that at this stage. It would be interesting to see if prosecution decide to tackle this.