Let's add another perspective to reaching 1:53/2:03 in 50 years.
For the men, in the last 50 years, the marathon record fell 11 minutes. To expect another drop of 11 minutes in the next 50 years, is to expect a linear progression in the drop in times.
For the women, since marathon times are only just maturing, we can not realistically go back 50 years. Going back to 1985, in 18 years the women's marathon time dropped about 5 minutes. Expecting a drop to 2:03, say in 54 years, is another 12 minute drop, averaging 4 minutes per 18 year period. This is also a fairly linear progression.
Now at some point in the future, the "linear" model breaks down. If not, after 550 years, the record marathon will have finished before it's even started, and man will most certainly be constrained by relativity. Most statisticians, and runners, believe that some sort of exponential decay better represents the trend, as men and women asymptotically approach the limits of the human body.
And we know there must be some human limits: the muscles and liver can only store so much energy; outside energy can only be ingested at a maximum rate; the efficiency of energy creation, even for the most efficient athletes, is poor (most of it is lost as heat); some minimum amount of energy must be used to propel a substantial body mass over the whole distance; energy creation, from all sources, occurs at some maximum rates; energy creation produces heat, which can only be dissipated at some maximum rate; their is a maximum temperature the human body can sustain and still live.
Although I don't want to doom any future athletes with negative thinking, given the maturity of the sports now, how realistic is it to claim that a linear progression will last 50 more years for men or women?
We do know that future generations change subtly. The trend is that man is getting taller. Perhaps other subtle changes or mutations will push some of these limits further than ever before, allowing previously unbelievable improvements. If we compare Geb's hand-picked, rabbited time trialed world record attempts to Sergai Popov's 1958 world record, we must ask ourselves, will the next 50 years see the same magnitude of changes that these two performances have?